Relationship between β-amyloid protein 1-42, thyroid hormone levels and the risk of cognitive impairment after ischemic stroke

Table 1 Baseline clinical characteristics in non-post stroke cognitive impairment and post stroke cognitive impairment patients, n (%)

Variable	PSCI, n = 72	Non-PSCI, n = 116		P value
Age in yr	73 (66-80)	65 (60-74)		< 0.001
Gender, male/female	38/34	79/37		0.027
BMI as kg/m2	24.5 ± 2.6	23.8 ± 2.7		0.081
Education levels				0.011
Illiterate	26 (36.1)	24 (20.7)
Primary school	32 (44.4)	48 (41.4)
Postsecondary school	14 (19.4)	44 (37.9)
Smoking	13 (18.1)	26 (22.4)		0.449
Drinking	8 (11.1)	17 (14.7)		0.448
SBP as mmHg	152 ± 24	147 ± 26		0.189
DBP as mmHg	85 ± 12	83 ± 10		0.219
TC as mmol/L	4.54 ± 0.78	4.58 ± 0.72		0.720
TG as mmol/L	1.48 ± 0.57	1.31 ± 0.41		0.019
HDL as mmol/L	1.19 ± 0.17	1.12 ± 0.22		0.204
LDL as mmol/L	2.85 ± 0.71	2.34 ± 0.76		< 0.001
Aβ1-42 as pg/mL	363.0 ± 37.8	402.2 ± 35.3		< 0.001
hs-CRP as mg/L	4.8 ± 4.6	6.2 ± 7.1		0.138
Hcy as µmol/L	15.8 ± 8.2	15.0 ± 8.6		0.529
T3 as nmol/L	1.23 ± 0.59	1.47 ± 0.77		0.025
T4 as nmol/L	117.2 ± 26.4	110.5 ± 21.4		0.058
FT3 as pmol/L	4.68 ± 0.85	4.42 ± 0.93		0.056
FT4 as pmol/L	13.03 ± 2.26	16.47 ± 3.84		<0.001
TSH as mU/L	1.22 ± 0.64	1.41 ± 0.75		0.076
History of disease
Hypertension	25 (34.7)	37 (31.9)		0.674
Hyperlipidemia	3 (4.2)	9 (7.8)		0.284
Diabetes	16 (22.2)	28 (24.1)		0.750
Stroke/TIA	19 (26.4)	17 (14.7)		0.041
Myocardial infarction	2 (2.8)	3 (2.6)		0.930
Atrial fibrillation	9 (12.5)	5 (4.3)		0.037
NIHSS score on admission	7.2 ± 3.7	5.1 ± 2.9		< 0.001
Cerebral infarction volume in cm3	11.14 ± 2.25	10.86 ± 1.98		0.372
Lesion location
Posterior circulation	16 (22.2)	33 (28.4)		0.313
TOAST				0.890
Large-artery atherosclerosis	39 (54.2)	58 (50)
Cardioembolism	6 (8.3)	8 (6.9)
Small-artery occlusion Lacunar	21 (29.2)	37 (31.9)
Other determined etiology	5 (6.9)	9 (7.8)
Undetermined etiology	1 (1.4)	4 (3.4)
Medications during hospitalization
Hypoglycemic	13 (18.1)	23 (19.8)		0.759
Antihypertensive	35 (48.6)	53 (45.7)		0.681
Lipid-lowering drugs	54 (75.0)	81 (69.8)		0.411
Antiplatelet	65 (90.3)	104 (89.7)		0.888

Data are presented as mean ± SD or median (interquartile range). PSCI: Post stroke cognitive impairment; BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; TC: Total cholesterol; TG: Triglyceride; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; Aβ1-42: β-amyloid protein1-42; hs-CRP: Hypersensitive C-reactive protein; Hcy: Homocysteine; T₃: Triiodothyronine; T₄: Thyroxin; FT₃: Free triiodothyronine; FT₄: Free thyroxin; TSH: Thyrotropin; TIA: Transient ischemic attack; NIHSS: National Institutes of Health Stroke Scale.