Prognostic factors for overall survival in prostate cancer patients with different site-specific visceral metastases: A study of 1358 patients

Table 7 Multivariable Cox regression analysis of prognostic factors affecting overall survival in prostate cancer patients with lung, brain, and liver metastases

Variable	Lung			Brain			Liver
	HR	95%CI	P value	HR	95%CI	P value	HR	95%CI	P value
Age (yr)
≤ 70	Ref.			Ref.			Ref.
> 70	2.084	1.601-2.712	< 0.001	0.994	0.553-1.785	0.983	1.499	1.099-2.043	0.010
Grade1
I/II	Ref.
III/IV	2.031	0.879-4.692	0.097
Unknown	NA	NA	NA
T stage
T1/T2	Ref.			Ref.			Ref.
T3/T4	1.490	1.135-1.958	0.004	1.785	1.007-3.163	0.047	1.021	0.737-1.414	0.900
Unknown	NA	NA	NA	NA	NA	NA	NA	NA	NA
Gleason score
≤ 8	Ref.						Ref.
> 8	1.735	1.315-2.289	< 0.001				1.688	1.224-2.327	0.001
Unknown	NA	NA	NA				NA	NA	NA
Bone metastases
No	Ref.
Yes	1.327	0.961-1.833	0.086
Unknown	NA	NA	NA

¹I: Well differentiated; II: Moderately differentiated; III: Poorly differentiated; IV: Undifferentiated. All variables with Unknown Data did not fit in Cox and Kaplan–Meier model. NA: Not available; PSA: Prostate-specific antigen.