Prognostic factors for overall survival in prostate cancer patients with different site-specific visceral metastases: A study of 1358 patients

Table 6 Univariate Cox regression analysis of prognostic factors affecting overall survival in prostate cancer patients with lung, brain, and liver metastases

Variable	Lung			Brain			Liver
	HR	95%CI	P value	HR	95%CI	P value	HR	95%CI	P value
Marital status
Married	Ref.			Ref.			Ref.
Never married	0.924	0.757-1.127	0.436	1.169	0.738-1.853	0.506	0.950	0.754-1.198	0.667
Unknown	NA	NA	NA	NA	NA	NA	NA	NA	NA
Age (yr)
≤ 70	Ref.			Ref.			Ref.
> 70	1.728	1.471-2.029	< 0.001	1.502	1.025-2.202	0.037	1.349	1.111-1.637	0.003
Race
Black	Ref.			Ref.			Ref.
White	1.078	0.888-1.310	0.447	1.130	0.685-1.865	0.632	1.130	0.892-1.432	0.310
Other	0.824	0.572-1.187	0.299	1.562	0.652-3.741	0.317	0.923	0.568-1.499	0.745
Unknown	NA	NA	NA	NA	NA	NA	NA	NA	NA
Grade1
I/II	Ref.			Ref.			Ref.
III/IV	2.063	1.098-3.877	0.024	2.416	0.741-7.874	0.144	1.332	0.788-2.253	0.284
Unknown	NA	NA	NA	NA	NA	NA	NA	NA	NA
T stage
T1/T2	Ref.			Ref.			Ref.
T3/T4	1.476	1.203-1.811	< 0.001	1.786	1.015-3.145	0.044	1.318	1.033-1.681	0.026
Unknown	NA	NA	NA	NA	NA	NA	NA	NA	NA
N stage
N0	Ref.			Ref.			Ref.
N1	1.136	0.942-1.368	0.182	0.957	0.587-1.559	0.859	1.128	0.903-1.410	0.289
Unknown	NA	NA	NA	NA	NA	NA	NA	NA	NA
PSA (ng/mL)
≤ 10	Ref.			Ref.			Ref.
> 10	0.779	0.603-1.005	0.055	1.506	0.752-3.017	0.248	0.781	0.581-1.049	0.101
Unknown	NA	NA	NA	NA	NA	NA	NA	NA	NA
Gleason score
≤ 8	Ref.			Ref.			Ref.
> 8	1.848	1.446-2.361	< 0.001	1.322	0.661-2.643	0.430	1.533	1.154-2.036	0.003
Unknown	NA	NA	NA	NA	NA	NA	NA	NA	NA
Bone metastases
No	Ref.			Ref.			Ref.
Yes	1.246	1.013-1.533	0.038	1.258	0.748-2.115	0.388	1.029	0.817-1.296	0.807
Unknown	NA	NA	NA	NA	NA	NA	NA	NA	NA

¹I: Well differentiated; II: Moderately differentiated; III: Poorly differentiated; IV: Undifferentiated. All variables with Unknown Data did not fit in Cox and Kaplan–Meier model. NA: Not available; PSA: Prostate-specific antigen.