Prognostic factors for overall survival in prostate cancer patients with different site-specific visceral metastases: A study of 1358 patients

Table 3 Univariate and multivariable Cox regression analyses of prognostic factors affecting overall survival in prostate cancer patients with a single site of visceral metastasis

Variable	Univariate analysis			Multiple analysis
	HR	95%CI	P value	HR	95%CI	P value
Marital status
Married	Ref.
Never married	1.030	0.873-1.215	0.726
Unknown	NA	NA	NA
Age (yr)
≤ 70	Ref.			Ref.
> 70	1.557	1.353-1.792	< 0.001	1.593	1.265-2.007	< 0.001
Race
Black	Ref.
White	1.140	0.963-1.351	0.129
Other	0.788	0.565-1.100	0.162
Unknown	NA	NA	NA
Grade1
I/II	Ref.			Ref.
III/IV	1.577	1.005-2.473	0.047	1.125	0.642-1.973	0.681
Unknown	NA	NA	NA	NA	NA	NA
T stage
T1/T2	Ref.			Ref.
T3/T4	1.239	1.034-1.486	0.020	1.025	0.799-1.314	0.849
Unknown	NA	NA	NA	NA	NA	NA
N stage
N0	Ref.
N1	1.162	0.988-1.368	0.070
Unknown	NA	NA	NA
PSA (ng/mL)
≤ 10	Ref.
> 10	0.887	0.698-1.129	0.331
Unknown	NA	NA	NA
Gleason score
≤ 8	Ref.			Ref.
> 8	1.736	1.401-2.151	< 0.001	1.609	1.260-2.055	< 0.001
Unknown	NA	NA	NA	NA	NA	NA
Bone metastases
No	Ref.			Ref.
Yes	1.282	1.071-1.534	0.007	1.406	1.053-1.877	0.021
Unknown	NA	NA	NA	NA	NA	NA
Lung	Ref.			Ref.
Brain	1.548	1.209-1.983	0.001	1.257	0.778-2.029	0.350
Liver	1.682	1.444-1.959	< 0.001	1.857	1.460-2.361	< 0.001

¹I: Well differentiated; II: Moderately differentiated; III: Poorly differentiated; IV: Undifferentiated. All variables with Unknown Data did not fit in Cox and Kaplan–Meier model. NA: Not available; PSA: Prostate-specific antigen.