Bilateral adrenocortical adenomas causing adrenocorticotropic hormone-independent Cushing’s syndrome: A case report and review of the literature

doi:10.12998/wjcc.v7.i8.961

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Apr 26, 2019 (publication date) through Feb 18, 2025

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Apr 26, 2019; 7(8): 961-971
Published online Apr 26, 2019. doi: 10.12998/wjcc.v7.i8.961

Table 1 Endocrinological study at different periods of bilateral adrenocortical adenomas

Baseline					Low-dose dexam test	High-dose dexam test
		00:00 h	08:00 h	16:00 h	Low-dose dexam test	High-dose dexam test
Before the operation	ACTH (pmol/L)	4.26	4.13	3.62	3.51	4.1
	F (nmol/L)	606.42	761	618.08	579.34	689.18
	UFC (nmol/L)	1650.7	-	-	3073.5	2122.6
After unilateral operation	ACTH (pmol/L)	7.84	7.86	7.7	9.28	-
	F (nmol/L)	391.78	440.08	455.65	414.36	-
	UFC (nmol/L)	1024.9	-	-	1117	-
After bilateral operations	ACTH (pmol/L)	4.66	4.86	3.66	4.93	-
	F (nmol/L)	<25.7	<25.7	<25.7	<25.7	-
	UFC (nmol/L)	-	<25.7	-	-	-

Reference range: ACTH at 8 AM, <10.12 pmol/L; F at 8 AM, 198.7-797.5 nmol/L; 4 PM: 85.3-459.6 nmol/L; 0 AM: 0-165.7 nmol/L; UFC: 98.0-500.1 nmol/24 h; dexam: Dexamethasone; ACTH: Adrenocorticotropic hormone; F: Cortical; UFC: Urine free cortisol.

Citation: Gu YL, Gu WJ, Dou JT, Lv ZH, Li J, Zhang SC, Yang GQ, Guo QH, Ba JM, Zang L, Jin N, Du J, Pei Y, Mu YM. Bilateral adrenocortical adenomas causing adrenocorticotropic hormone-independent Cushing’s syndrome: A case report and review of the literature. World J Clin Cases 2019; 7(8): 961-971
URL: https://www.wjgnet.com/2307-8960/full/v7/i8/961.htm
DOI: https://dx.doi.org/10.12998/wjcc.v7.i8.961