Adiponectin gene polymorphisms and risk of gestational diabetes mellitus: A meta-analysis

Table 3 Main results of the pooled odds ratios in meta-analysis for the association between ADIPOQ polymorphisms and gestational diabetes mellitus

SNP	N	Sample size		Allelic model		Dominant model		Recessive model
		Case	Control	OR (95%CI)	P	OR (95%CI)	P	OR (95%CI)	P
+45T/G
Total	10	1024	1059	1.45 (1.26-1.67)	0.000a	1.50 (1.25-1.79)	0.000a	2.00 (1.42-2.84)	0.000a
Subgroup
Ethnicity
Asian	8	945	890	1.47 (1.27-1.70)	0.000a	1.54 (1.27-1.85)	0.000a	2.00 (1.43-2.85)	0.000a
SA	1	79	169	1.21 (0.68-2.41)	0.510	1.13 (0.59-2.15)	0.710	2.18 (0.43-11.07)	0.350
+276G/T
Total	5	590	595	0.88 (0.74-1.05)	0.158	0.91 (0.65-1.26)	0.561	0.82 (0.64-1.05)	0.118
-11377C/G
Total	5	722	791	0.96 (0.72-1.26)	0.750	1.00 (0.73-1.37)	0.980	0.90 (0.61-1.32)	0.570
Subgroup
Ethnicity
Asian	2	309	286	1.04 (0.77-1.41)	0.800	1.09 (0.79-1.50)	0.600	0.97 (0.51-1.86)	0.930
SA	1	79	168	0.80 (0.50-1.29)	0.360	0.77 (0.44-1.36)	0.370	0.81 (0.28-2.34)	0.690
European	2	334	337	0.94 (0.45-1.96)	0.870	1.00 (0.42-2.33)	0.990	0.87 (0.51-1.49)	0.610

^aP < 0.01. ADIPOQ: Adiponectin; SA: South American; GDM: Gestational diabetes mellitus; SNP: Single nucleotide polymorphism; N: Number of studies; OR: Odds ratio; CI: Confidence interval; NA: Not assessable.