Immune checkpoint inhibitor-induced colitis: A comprehensive review

Table 2 Grading the severity of immune checkpoint inhibitor-induced colitis and diarrhea based on Common Terminology Criteria for Adverse Events grade

	Colitis	Diarrhea
Grade 1	Asymptomatic	Increase of < 4 stools/d over baseline
Grade 2	Abdominal pain, mucus, blood in stool	Increase of 4-6 stools/d
Grade 3	Severe pain, fever, peritoneal signs	Increase of ≥ 7 stools/d
Grade 4	Life-threatening consequences such as perforation, ischemia, necrosis, bleeding, toxic megacolon	Life-threatening consequences such as hemodynamic collapse
Grade 5	Death	Death

Adapted from the Cancer Therapy Evaluation Program, National Cancer Institute Common Terminology Criteria for Adverse Events v5.0 Program, Common Terminology Criteria for Adverse Events v5.0.

https://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf.