Distant metastasis in choroidal melanoma with spontaneous corneal perforation and intratumoral calcification: A case report

Figure 3 Histological findings of the resected tumor specimens. A: Tumor cells occupied the entire eyeball (×40); B: Ossification was noted in the tumor (×200); C: Uveal tissue was confined in the region of the perforated cornea. Intact cornea layers and no corneal thinning or corneal ulcer was noted (×40); D: Immunohistochemistry (IHC) revealed diffusely positive melanin-A immunostaining in the cytoplasm of primary tumor cells (Red chromogen, ×400); E: IHC revealed diffusely positive SOX-10 immunostaining in the nuclei of primary tumor cells (Red chromogen, ×400); F: Primary epithelioid tumor cells showed strong nuclear labeling for BAP1 expression (Red chromogen, ×400).