Mixed serous-neuroendocrine neoplasm of the pancreas: A case report and review of the literature

Table 3 Clinicopathological characteristics between Von Hippel-Lindau-associated and non-Von-Hippel-Lindau-associated mixed serous-neuroendocrine neoplasms

Characteristic	VHL	Non-VHL	P
Case number	5	17
Sex (female:male)	4:1	15:2	0.637
Age	33 (28-39)	55 (25-78)	<0.001
DT PSCN	4/5 (80%)	5/17 (29%)	0.043
PanNET size (cm)	3.7 (2.8-5)	1.7 (0.3-5)	0.016
Invasion	4/5 (80%)	6/17 (35%)	0.078
IHC hormone expression	2/5 (40%)	7/17 (41%)	0.962
Other tumors	4/5 (80%)	3/17 (18%)	0.009

DT: Diffuse type; IHC: Immunohistochemical staining; MSNN: Mixed serous-neuroendocrine neoplasm; PSCN: Pancreatic serous cystic neoplasm; PanNET: Pancreatic neuroendocrine tumor; VHL: Von Hippel-Lindau syndrome.