Comparison of intra-articular injection of parecoxib vs oral administration of celecoxib for the clinical efficacy in the treatment of early knee osteoarthritis

Table 4 Comparison of inflammatory cytokine levels in the synovial fluid in the three groups before and after treatment

Group	Case	IL-6 (pg/mL)		TNF-α (pg/mL)		IL-10 (pg/mL)
		Before	After	Before	After	Before	After
Group A	37	418.7 ± 27.8	384.1 ± 25.0b	3.66 ± 0.38	3.03 ± 0.28b	5.47 ± 0.32	6.04 ± 0.49b
Group B	37	415.7 ± 28.2	212.6 ± 23.4b	3.53 ± 0.47	2.07 ± 0.33b	5.52 ± 0.30	7.46 ± 0.44b
Group C	36	412.7 ± 37.1	137.8 ± 29.0b	3.56 ± 0.53	1.45 ± 0.26b	5.42 ± 0.43	8.72 ± 0.60b
F value		0.34	871.17	0.70	275.41	0.87	246.74
P value		0.715	< 0.001	0.497	< 0.001	0.422	< 0.001

^bComparison of interleukin-6, Tumor necrosis factor-α and interleukin-10 levels for each group before and after treatment, significant differences were found (P < 0.001). Data are presented as mean ± SD of pg/mL. IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-α; IL-10: Interleukin-10.