Overview of organic anion transporters and organic anion transporter polypeptides and their roles in the liver

Table 2 Organizational characteristics and substrates of human organic anion transporter polypeptides[4,25,69,73,153,154,155,156]

Protein name	Coding gene	Chromosome localization	Distribution location	Substrates (Km value)
OATP1A2	SLCO1A2	12p12.1	Brain, liver, kidney	Bile salts, bilirubin, ciprofloxacin, estrone-3-sulfate (59 μmol), methotrexate, N-methylquinidine (26 μmol), norfloxacin, PGE2, taurochenodeoxycholate (19 μmol)
OATP1B1	SLCO1B1	12p12.1	Liver	Benzylpenicillin, bile acid, bilirubin (8 μmol), estradiol-17b-glucuronide (8 μmol), estrone-3-sulfate (0.2 μmol), methotrexate, olmesartan, pravastatin (35 μmol), taurocholate (10-34 μmol), steroid hormone
OATP1B3	SLCO1B3	12p12.2	Liver	Benzylpenicillin (penicillin G), bilirubin (39 μmol), bile acid, cholecystokinin octapeptide (CCK-8; 11 μmol), docetaxel, eicosanoid, estradiol-17β-glucuronide (5.4 μmol), methotrexate (25 μmol), paclitaxel (7 μmol), rosuvastatin, saquinavir, steroid hormone, taurocholate (6 μmol)
OATP1C1	SLCO1C1	12p12.2	Brain, testis	Bromosulfophthalein, estrone-3-sulphate, thyroid hormones (0.1 μmol)
OATP2A1	SLCO2A1	3q22.1-q22.2	Brain, colon, heart, kidney, liver, small intestine, stomach	PGH2, PGE1 (82 μmol), PGE2 (100 μmol), PGF2a (92 μmol), thromboxane B2 (182 μmol)
OATP2B1	SLCO2B1	11q13.4	Liver, intestinal epithelium, placenta, epidermal keratin, breast, heart, skeletal muscle, brain	Benzylpenicillin, bilirubin, dehydroepiandrosterone-3-sulphate, estrone-3-sulphate (5 μmol), fexofenadine, montelukast, pravastatin, pitavastatin, PGE2, talinolol, statins, steroids, taurocholate
OATP3A1	SLCO3A1	15q26.1	Testis, brain, heart, lung, spleen	Benzylpenicillin, estrone-3-sulphate, PGE1, PGE2, PGF2a, steroid hormone
OATP4A1	SLCO4A1	20q13.33	Heart, placenta, lung, liver, skeletal muscle, kidney, pancreas	Bile salts, estrone-3-sulphate, PGE2, taurocholate (15 μmol), steroid hormone
OATP4C1	SLCO4C1	5q21.1	Liver	Bile salts, cAMP, digoxin (8 μmol), estrone-3-sulphate, methotrexate, steroid hormone
OATP5A1	SLCO5A1	8q13.3	Fetal brain, prostate, skeletal muscle	Satraplatin
OATP6A1	SLCO6A1	5q21.1	Testis, spleen, brain, fetal brain, placenta	Unknown