Primitive neuroectodermal tumors of the abdominal wall and vulva in children: Report of two cases and review of the literature

Table 2 Thirteen reported cases of primitive neuroectodermal tumor in the abdominal wall

Ref.	Age	Sex	Size (cm)	Immuno-histo-chemistry	Molecular/cyto-genetic analysis	MATOD	Therapy	Follow-up	Relapse	Outcome
Roncati et al[9], 2015	45 yr	M	1.5	NSE, CD99 (+)	FISH (+)	NA	NA	NA	NA	NA
Riccardi et al[18], 2010	15 yr	M	2.5-3.0	CD99, NB84a, vimentin (+)	FISH, RT-PCR (-)	No	S + Ch	NA	NA	NA
Betal et al[19], 2009	61 yr	F	NA	CD99, CD56, cytokeratins, S100 (+)	NA	No	S + Ch (6 cycles of VDC)	NA	No	NA
Taylor et al[8], 2000	33 mo	M	3.5 × 3.5 × 2.5	CD99 (+)	NA	No	S	10 yr	No	Survival
Soma et al[20], 2015	21 yr	F	6 × 4	CD 99, vimentin (+)	NA	No	S + Ch (VDC)	6 mo	No	Survival
Somers et al[21], 2004	16 yr	F	1.5	CD99, CD56, S100 (+)	FISH and RT-PCR (-)	No	Before metastasis: S + Ch (6 cycles of VAC); after metastasis: S + RT + CT (1 cycle of IE + CBP)	NA	Yes	Death
Savić et al[22], 2017	15 yr	M	3.8 × 2.6 × 3.7	CD99, vimentin, synaptophysin (+)	RT-PCR (+)	No	S + Ch (VAC) + RT	8m	No	Survival
Askri et al[23], 2008	35 yr	F	6.5 × 4	CD99 (+)	NA	NA	S + Ch (3 cycles of VDC )	NA	NA	NA
Gurria et al[24], 2011	23 yr	F	14 × 10 × 7	CD99, PAS (+)	NA	No	S + RT + Ch (VAC/IE)	8 mo	No	Survival
Aydinli et al[25], 2009	65 yr	M	5	CD99 (+)	NA	NA	S + Ch (6 cycles of VDCE)	1 yr	No	Survival
Wang et al[26], 2017	21 yr	F	5 × 4	CD99, vimentin, NSE (+)	NA	Yes	S + RT + Ch (VAC)	7 mo	Yes	Death
Zhan et al[27], 2012	2 yr	F	5.0 × 3.8 × 5.1	positive CD99, NSE, Ki67 (+)	NA	No	S + Ch (CTX + ADM + DDP)	1 yr	No	Survival
Present case, 2019	66 mo	F	3.4 × 6.1 × 2	CD99, Syn (+)	NA	No	S + Ch (VDC/IE)	66 mo	No	Survival

+: Positive; MATOD: Metastatic at the time of diagnosis; S: Surgery; Ch: Chemotherapy; RT: Radiotherapy; NA: Not available; FISH: Fluorescence in situ hybridization; RT-PCR: Reverse transcription-PCR; VAC: Vincristine and actinomycin D, cyclophosphamide; IE: Ifosfamide and etoposide; VDC: Vincristine, doxorubicin, and cyclophosphamide.