Methotrexate-related lymphoproliferative disorders in the liver: Case presentation and mini-review

Table 2 Summary of 10 reported cases of methotrexate-associated lymphoproliferative liver tumors

Ca-se	Ref.	Age	Sex	Sym-ptom	MTX peri-od (yr)	Num-ber of tu-mors	CT	MRI	PET	US	CE-US	Ti-ssue Colle-ction	Path-ology	Immunohisto-chemistry	Treat-ment	Re-spon-se	Re-currence	On-set pa-ttern	Prog-nosis
1	9	68	F	Ma-laise	8	Mul-tiple	Low den-sity hypovas-cular	N/A	N/A	Hypo-echoic	N/A	US-gui-ded	Hodg-kin lym-pho-ma	CD15+, CD20-, CD30+	Un-trea-ted	No re-spon-se	None	Persis-tent	Death
2	10	76	M	None	4.5	Single	Low den-sity hypovas-cular		N/A	Hypo-echoic	N/A	Sur-gery	B cell	CD10-, CD20+, CD79a+	Resec-tion, cessa-tion	Effec-tive	None	Re-gre-ssive	Alive (10 mo)
3	11	67	F	Abdo-minal pain, fever	6	Mul-tiple	Low den-sity hypovas-cular	N/A	High up-take	N/A	N/A	US-gui-ded	B cell	CD10-, CD20+, CD5-, EBER+	R-THP-COP	Effec-tive	None	Persis-tent	Alive (1 yr)
4	12	56	F	Weig-ht loss, fever	7	Mul-tiple	Iso den-sity hypovas-cular	N/A	High up-take	N/A	N/A	US-gui-ded	B cell	CD10+, CD20+, CD5-	R-CH-OP	Effec-tive	None	Persis-tent	Alive (6 mo)
5	13	64	M	Abdo-minal pain, fever	2	Mul-tiple	Low den-sity hypovas-cular	N/A	N/A	N/A	N/A	US-gui-ded	B cell	CD10+, CD79a+, CD20+; Bcl-2-, CD3-, EBER-	R-CH-OP	Effec-tive	None	Persis-tent	Alive (2 yr)
6	14	65	F	None	7	Single	Low den-sity mild enhance-ment	T1: low, T2: high, diffu-sion: high	N/A	Hypo-echoic	N/A	Sur-gery	B cell	CD10-, CD15-, CD20+, CD30+, CD79a+, EBER+	Resec-tion, cessa-tion	Effec-tive	None	Re-gre-ssive	Alive (1 yr)
7	15	70	F	Abdo-minal pain	10	Single	Low den-sity hypovas-cular	T1: low, T2: high, diffu-sion: high	N/A	N/A	N/A	Surgery	T cell	CD10-, CD20-, CD79a-, CD3+, CD45RO+, CD5+, bcl-2-, EBER-	Resec-tion, cessa-tion	Effec-tive	None	Re-gre-ssive	Alive (1 yr)
8	16	76	F	Ano-rexia	9	Mul-tiple	Low den-sity	N/A	N/A	N/A	N/A	US-gui-ded	T and B cell	N/A	Cessa-tion	Effec-tive	None	Re-gre-ssive	Alive (N/A)
9	17	63	M	Abdo-minal pain	10	Mul-tiple	Low den-sity	N/A	High up-take	Hypo-echoic	Hypovas-cular	US-gui-ded	B cell	N/A	Cessa-tion	Effec-tive	None	Re-gre-ssive	Alive (7 mo)
10	Our case	70	F	Abdo-minal pain, fever	5	Mul-tiple	Low den-sity hypovas-cular	T1: low, T2: high	N/A	Hypo-echoic	Hypovas-cular	US-gui-ded	T and B cell	CD3+, CD4+, CD8+, CD56-, CD20-, CD79a+, EBER-	Cessa-tion	Effec-tive	None	Re-gre-ssive	Alive (2 yr)

N/A: Information not applicable; CD: Cluster of differentiation; EBER: Epstein-Barr virus-encoded small RNA; R-THP-COP: Rituximab–Pirarubicin-Cyclophosphamide–Oncovin-Prednisolone; R-CHOP: Rituximab–Cyclophosphamide–Doxorubicin Hydrochloride–Oncovin-Prednisolone.