First Italian outbreak of VIM-producing Serratia marcescens in an adult polyvalent intensive care unit, August-October 2018: A case report and literature review

Table 2 Clinical and epidemiological data of patients

Patient	Admission from	Age(yr)	Sex	Underlying disease(s)	Previous AT	Admission diagnosis	Date of admission	Stool screening	1° site of identifi-cation
1	Community	49	M	SC	No	DNM	May, 28	Yes	Blood
1	ICU	49	M	SC	Yes	DNM	May, 28	Yes	Blood
2	Community	69	F	rUTI	Yes	SS	Sep, 9	Yes	RS
3	Internal ward	67	F	PPD, DM, UC, SHT, HCM	Yes	HS	Sep, 17	Yes	RT
Patient	Infection (1° site)	Date of 1° isolation	2° site of identification	Infection (2° site)	Date of the 2° isolation site	Initial AT	Final AT	AT duration(d)	Outcome
1	Yes	Aug, 1	RS	No	Aug, 4	CZA + GEN	CZA + GEN	14	Favourable
1	Yes	Aug, 17	-	-	-	AMK + FOF	AMK + MEM	47	Favourable
2	No	Sep, 20	RT	Yes	Sep, 20	C/T + MTZ	C/T + MTZ + CPT	14	Death
3	No	Sep, 24	Urine	No	Sep, 28	AFG + TGC + TZP	CST + SAM + CZA + AMK + AFG	16	Death

AFG: Anidulafungin; AMK: Amikacin; AT: Antibiotic treatment; CPT: Ceftaroline; CST: Colistin; C/T: Ceftolozane-tazobactam; CZA: Ceftazidime-avibactam; DM: Diabetes mellitus; DNM: Descending necrotizing mediastinitis; FOF: Fosfomycin; GEN: Gentamicin; HCM: Hypertrophic cardiomyopathy; HS: Hypovolemic hemorrhagic shock; ICU: Intensive care unit; MEM: Meropenem; MTZ: Metronidazole; PPD: Paranoid personality disorder; RS: Rectal swab; RT: Respiratory tract; SAM: Ampicillin-sulbactam; SC: Schizophrenia; SHT: Hypothyroidism; SS: Septic shock; TGC: Tigecycline; TZP: Piperacillin-tazobactam; UC: Ulcerative Colitis; rUTI: Recurrent urinary tract infection.