Irritable bowel syndrome and functional constipation management with integrative medicine: A systematic review

doi:10.12998/wjcc.v7.i21.3486

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World Journal of Clinical Cases

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2307-8960

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Systematic Review

World J Clin Cases. Nov 6, 2019; 7(21): 3486-3504
Published online Nov 6, 2019. doi: 10.12998/wjcc.v7.i21.3486

Table 3 Strengths of recommendations regarding pharmacological interventions for functional constipation in 14 clinical practice guidelines

Category	Drugs	Recommendations by CPGs
Bulking agents	Psyllium	Strongly recommended or recommended by 10 CPGs
Bulking agents	Bran	Recommended by 2 CPGs, insufficient evidence reported by 6 CPGs
Stool softeners	Docusate sodium	Insufficient evidence reported by 4 CPGs
	Liquid paraffin	Insufficient evidence reported by 4 CPGs
	Glycerin	Insufficient evidence reported by 4 CPGs
Osmotic laxatives	PEG	Strongly recommended or recommended by 10 CPGs
	Lactulose	Recommended by 10 CPGs
	Magnesium salts	Recommended by 1 CPG, insufficient evidence reported by 2 CPGs
Stimulant laxatives	Bisacodyl	Recommended by 9 CPGs, weak evidence reported by 1 CPG, insufficient evidence reported by 1 CPG
	Sodium picosulfate	Recommended by 9 CPGs, weak evidence reported by 1 CPG, insufficient evidence reported by 1 CPG
	Senna	Insufficient evidence reported by 6 CPGs
Prosecretory agents	Lubiprostone	Strongly recommended or recommended by 7 CPGs
Prosecretory agents	Linaclotide	Strongly recommended or recommended by 7 CPGs
Others	Prucalopride	Strongly recommended or recommended by 9 CPGs
	Probiotics	Insufficient evidence reported by 6 CPGs
	Enema and suppositories	Weak evidence reported by 6 CPGs, Strongly recommended by 1 CPG (CO₂-releasing suppositories for distal constipation)

PEG: Polyethylene glycol; CPG: Clinical practice guidelines.

Citation: Dai L, Zhong LL, Ji G. Irritable bowel syndrome and functional constipation management with integrative medicine: A systematic review. World J Clin Cases 2019; 7(21): 3486-3504
URL: https://www.wjgnet.com/2307-8960/full/v7/i21/3486.htm
DOI: https://dx.doi.org/10.12998/wjcc.v7.i21.3486