Nomograms for pre- and postoperative prediction of long-term survival among proximal gastric cancer patients: A large-scale, single-center retrospective study

Table 2 Preoperative analysis of overall survival

	Univariate analysis		Multivariate analysis
Variable	HR (95%CI)	P value	HR (95%CI)	P value
Preoperative tumor size(cm)		< 0.001		0.012
< 5	Ref		Ref
≥ 5	2.953 (2.227-3.915)		1.480 (1.090-2.010)
Preoperative N stage		< 0.001		< 0.001
N0	Ref		Ref
N+	3.219 (2.428-4.268)		2.069 (1.536-2.787)
Preoperative T stage		< 0.001		< 0.001
T1-3	Ref		Ref
T4	4.550 (3.132-6.609)		2.767 (1.846-4.148)
Preoperative CA19-9 (U/mL)		< 0.001		0.003
< 33.35	Ref		Ref
≥ 33.35	2.250 (1.750-2.894)		1.569 (1.166-2.110)
ASA score		< 0.001		< 0.001
1	Ref		Ref
2	1.725 (1.299-2.289)		1.675 (1.257-2.230)
3	3.805 (2.677-5.409)		3.257 (2.271-4.670)
3- to 6-mo weight loss		< 0.001		0.036
No	Ref		Ref
Yes	1.588 (1.231-2.049)		1.316 (1.019-1.701)
Age (yr)		0.008
< 65	Ref
≥ 65	1.412 (1.095-1.821)
Gender		0.318
Female	Ref
Male	1.178 (0.854-1.625)
BMI (kg/m2)		0.473
<25	Ref
≥ 25	0.875 (0.609-1.259)
Accompanying disease		0.673
No	Ref
Yes	0.944 (0.724-1.232)
History of abdominal surgery		0.704
No	Ref
Yes	1.146 (0.566-2.321)
Preoperative Charlson score
0	Ref
1-2	1.007 (0.768-1.322)	0.959
≥ 3	2.202 (0.973-4.982)	0.058
Preoperative CEA (µg/mL)		<0.001
< 4	Ref
≥ 4	1.673 (1.294-2.164)
HB, g/L		0.265
≥ 9.0	Ref
< 9.0	1.239 (0.850-1.808)
ALB, g/L		0.014
≥ 35	Ref
< 35	1.410 (1.072-1.854)
Fibrinogen, g/L		0.003
< 4	Ref
≥ 4	1.471 (1.137-1.904)