Next generation sequencing reveals co-existence of hereditary spherocytosis and Dubin–Johnson syndrome in a Chinese gril: A case report

Table 1 The charactistics of the patient

Gender	Age	Onset age	Symptoms and signs
Female	21 years	Since birth	Anemia, severe jaundice, splenomegaly
Laboratory examination
		Before treatment	After treatment
HGB (g/L)		105	114
ARC (×1012/L)		0.2083	N/E
TBIL (μmol/L)		111.8	88.69
DBIL (μmol/L)		35.4	29.9
IBIL (μmol/L)		76.4	58.79
DBIL/TBIL (%)		31.7	33.7
NGS results
A de novo heterozygous mutation of the SPTB gene, c.2413 C > T (p.Gln805*)
The mutation of the ABCC2 gene from the father: c.4313+1 G > T
The mutation of the ABCC2 gene from the mother c.3629 G > A (R1210H)