Interventions to improve sarcopenia in cirrhosis: A systematic review

Table 5 Testosterone to improve sarcopenia in cirrhosis

Ref.	Study participants characteristics	Study design	Sample size	Intervention	Intervention	Diagnosis of sarcopenia	Results
Yurci et al[51], 2011	mean age: 52.17; mean BMI: 27.17; CTP score: 7; setting: Turkey	Quasi experimental (pre-post intervention study)	16	Testosterone gel 50 mg/d in hypo gonadal men	6 mo	Anthropometric measurement: Muscle strength and skin fold thickness	Muscle strength increased significantly 3 mo post intervention
Sinclair et al[52], 2016	mean Age: 55; male 100%; mean BMI: 28.8; CTP score: 9; setting: Australia	RCT	101	Intramuscular testosterone undecanoate in men with low testosterone	12 mo	APLM by DEXA	APLM and TBM were significant higher in testosterone-treated subjects. No change in mortality

APLM: Appendicular lean mass; BMI: Body mass index.