Changes of serum inflammatory factors and miR-145 expression in patients with osteoarthritis before and after treatment and their clinical value

Table 3 Receiver operating characteristic curve analysis of miR-145 and inflammatory factors in differentiating Kellgren-Lawrence grades

	miR-145	TNF-α	IL-6	IL-10
I-II
AUC	0.762	0.785	0.758	0.767
Critical level	1.356	142.00 ng/L	13.06 μg/L	64.37 pg/mL
Sensitivity	94.59%	59.46%	62.16%	67.57%
Specificity	51.61%	97.45%	90.32%	90.32%
II-III
AUC	0.587	0.631	0.766	0.663
Critical level	1.475	167.80 ng/L	19.62 μg/L	51.43 pg/mL
Sensitivity	32.43%	48.65%	97.30%	75.68%
Specificity	86.67%	86.68%	46.67%	60.00%

AUC: Area under the curve; TNF: Tumor necrosis factor; IL: Interleukin.