Sinusoidal obstruction syndrome: A systematic review of etiologies, clinical symptoms, and magnetic resonance imaging features

Table 4 Characteristic information of patients in 18 case series

No.	Authors	Country	Publication year	Patient enroll-ment	Patient No.	Year range	Sex (male/fe-male)	Age (range, average)	Primary disease	Etiology	Time of duration	Dia-gnostic method
1	Chen et al[33]	China	2016	Retro-spective	8	2006-2013	5/3	21-67, 42	/	Tusanqi	3-18 mo	Biopsy (5) Clinical manifesta-tions + imaging (3)
2	Xu[34]	China	2015	Retro-spective	11	2004-2012	9/2	37-65, 49	/	Tusanqi (350-800 g)	15-50 d	Biopsy (2) Clinical manifesta-tions + imaging (9)
3	Ye et al[35]	China	2015	Retro-spective	20	2010-2012	1/19	36-76, 51	Trauma or stroke	Tusanqi	10 d-6 mo	Biopsy (12) Clinical manifesta-tions + laboratory examina-tion + imaging (8)
4	Zheng et al[36]	China	2015	Retro-spective	4	2012-2014	4/0	45-66	Alcoholic liver cirrhosis, trauma, body pain	Tusanqi (600-1500 g)	1-4 mo	Clinical manifesta-tions + imaging
5	Ren et al[37]	China	2017	Retro-spective	239	2010-2017	151/88	15-86 (59.6 ± 10.9)	Trauma, hypertension, extravasated blood, URI	Tusanqi	UK	Biopsy (48), Clinical manifesta-tions + imaging
6	Geng et al[38]	China	2009	Retro-spective	4	2007-2008	1/3	42-72, 57	/	Tusanqi	12-60 d	Clinical manifesta-tions
7	Chen et al[39]	China	2012	Retro-spective	45	1998-2011	23/22	33-73, 57	Trauma	Tusanqi	2-16 wk	Biopsy (21) Clinical manifesta-tions + laboratory examina-tion + imaging (8)
8	Zhang et al[40]	China	2012	Retro-spective	15	2005-2011	12/3	42-65	/	Tusanqi	1-6 mo	Biopsy (6) DSA (1) Clinical manifesta-tions + laboratory examina-tion + MRI
9	Li et al[41]	China	2011	Retro-spective	4	2009-2011	2/2	27-63, 35	/	Tusanqi (3), chemo-therapy (1)	Tusanqi (1-3 mo)	Biopsy (2) Clinical manifesta-tions + imaging
10	Hu et al[42]	China	2011	Retro-spective	5	2006-2011	4/1	40-60	Trauma history (3), health fitness (1)	Tusanqi	≥1 mo	Biopsy (2) Clinical manifesta-tions + imaging
11	Li et al[43]	China	2015	Retro-spective	4	2009-2014	3/1	35-61	Myocar-dial infarction (1)	Tusanqi	/	UK
12	Li et al[44]	China	2014	Retro-spective	8	2011-2014	5/3	21-71, 44.9	/	Tusanqi (2) Chemo-therapy or immune suppres-sive therapy (9)	/	Biopsy
13	Yu et al[24]	China	2013	Retro-spective	6	2002-2012	1/5	10-62 (36.5 ± 20.2)	Trauma (5) Irregular menstrua-tion (1)	Tusanqi (200-700 g)	8-30 d	Biopsy
14	Rong[45]	China	2015	Retro-spective	51	2009-2015	36/15	20-79	Drinking (14) Hyperten-sion (1) Diabetes (1) TB (1) RA (1)	Tusanqi (27) HSCT (4),	3 d-4 yr	Biopsy (6) Clinical manifesta-tions + imaging
15	Pei et al[46]	China	2010	Retro-spective	6	2006-2008	2/4	17-46	/	Tusanqi (5)	30 d	Biopsy (3) Clinical manifesta-tions + imaging
16	Zhou et al[47]	Hong Kong, China	2014	Retro-spective	16	2009-2011	12/4	22-72, 55.6	/	Intake of Gynura segetum	UK	Liver transplanta-tion (1) Clinical manifesta-tions
17	Guo[48]	China	2015	Retro-spective	12	2013-2014	9/3	45-62, 53	/	Tusanqi	UK	Clinical manifesta-tions + imaging
18	Yang[49]	China	2018	Retro-spective	39	2010-2016	9/30	36-74, 59.18 ± 9.36	/	Pyrrolizi-dine alkaloid (PA)–containing herbals	UK	Clinical manifesta-tions + imaging

UK: Unknown.