Surveillance and diagnosis of hepatocellular carcinoma: A systematic review

Table 3 Annual HCC incidence in cirrhotic patients with HCV

Ref.	Location	n	Follow-up period	Study design	Incidence
	UNI/MULTI
Li et al[55]	US MULTI	17836	Median 2719.2 d in patients treated with IFN, and 396.4 d for the ones treated with DAAs	Retrospective	Annual incidence in cirrhotic patients 2.28% treated with DAA and 2.12% in patients treated with IFN. Annual incidence in patients with no treatment of 4.531%
Piñero et al[57]	Latin America MULTI	1400	Median 16 mo	Prospective	Accumulated incidence in cirrhotic patients of 3% at 1 year and 6% at 2 yr
Waziry et al[59]	Europe, Asia, North America, South America MULTI	11523	Median 5.5 yr in patients treated with IFN and 1 yr in patients treated with DAA	Meta-analysis	Annual incidence 1.14% in patients with SVR treated with IFN and 2.96% in patients SVR treated with DAA. After adjusting for age and follow-up period, no greater risk is observed in those treated with DAA
Nahon et al[63]	France Multi	1270	Median 67.5 mo	Prospective	2.6% in cirrhotic patients in SVR with DAA. In patients with SVR the annual incidence is 12%

UNI: Uni-center; MULTI: Multicenter; IFN: Interferon; DAA: Direct-acting antiviral; SVR: Sustained viral response.