Surveillance and diagnosis of hepatocellular carcinoma: A systematic review

Table 2 Annual incidence of HCC in cirrhotic patients by etiology

Ref.	Location	n	Follow-up period	Study design	Incidence
	UNI/MULTI
Tansel et al[42]	North America, Europe, Asia, Australia. MULTI	6528	Median 8 yr	Meta-analysis	1.007% (95%CI: 0.69–1.47)
Fattovich et al[43]	Europe MULTI	297	Median 66 yr	Retrospective	2.2% for hepatitis B virus and 2.5% for hepatitis C virus
Mancebo et al[44]	Spain UNI	450	Median 42 mo	Prospective	2.6%
Shibuya et al[45]	Japan MULTI	396 (134 stage III or IV)	Median 43 mo	Prospective	1.5% for PBC stage III/IV

UNI: Uni-center; MULTI: Multicenter.