Hypoallergenicity of a thickened hydrolyzed formula in children with cow’s milk allergy

Table 2 Characteristics of reactions (immediate and delayed) observed after cow’s milk introduction during the double-blind placebo-controlled food challenge performed before (n = 19) or after study inclusion (n = 10), n (%)

Characteristics of patients with immediate reactions (n = 5)
Types of reactions
Objective gastrointestinal complaints	5 (100.0)
Severe reaction	1 (20.0)
Moderate reaction	1 (20.0)
Mild reaction1	3 (60.0)
Time of reaction after the ingestion of first CMP dose, mean ± SD, min	98.0 (4.5)
Eliciting dose of CMP, mean ± SD, g	2.2 (1.3)
Cumulative dose of CMP, mean ± SD, g	4.7 (2.9)
Characteristics of patients with delayed reactions only (n = 24)
Types of reactions
Digestive and cutaneous symptoms2	2 (8.3)
Upper digestive symptoms (regurgitations and vomiting)2	8 (33.3)
Lower digestive symptoms (changes in stools frequency/consistency and bloody stools)2	9 (37.5)
Lower and upper digestive symptoms2	3 (12.5)
Eczema	1 (4.2)
Irritability/crying3	1 (4.2)
Cumulative dose of CMP, mean ± SD, g	3.9 (1.8)
Time of reaction after hospital discharge
Within 6 h	11 (45.8)
Between 6 and 12 h	5 (20.8)
> 24 h	8 (33.4)

¹These patients also presented delayed digestive reactions, such as diarrhoea or regurgitations, at an average of 3.7 ± 2.1 h after hospital discharge;

²associated with or without general symptoms such as crying, irritability, and changes in behaviour;

³this patient had a positive Skin Prick Test to cow’s milk. CMP: Cow’s milk proteins.