Hypoallergenicity of a thickened hydrolyzed formula in children with cow’s milk allergy

Table 1 Clinical and allergy characteristics of patients in the hypoallergenic population at inclusion (n = 29 patients), n (%)

Characteristics	n (%)
Age, mo	8.03 (7.43)
Male	16 (55.2)
Anthropometric characteristics at birth
WFA z-score, mean ± SD	0.1 (1.0)
LFA z-score, mean ± SD	0.2 (1.3)
HCA z-score, mean ± SD	1.0 (1.0)
Gestational age, mean ± SD, wk	38.5 (2.3)
Preterm	6 (20.7)
Anthropometric characteristics at inclusion
WFA z-score, mean ± SD	-0.3 (1.2)
LFA z-score, mean ± SD	0.0 (1.4)
WFL z-score, mean ± SD	-0.4 (1.0)
BMI-for-age z-score, mean ± SD	-0.4 (1.0)
HCA z-score, mean ± SD	0.7 (1.2)
Feeding history
Breastfeeding in the past	22 (75.9)
Duration of (exclusive and/or partial) breastfeeding, mean ± SD, wk	17.6 (16.2)
Duration of feeding with the formula taken before inclusion, mean ± SD, wk	10.8 (13.1)
Average volume of the formula taken before inclusion, mean ± SD, mL/d	655.2 (199.3)
Solid foods diversification	18 (62.1)
Allergy history
At least one parent or sibling with a medically confirmed allergy	14 (48.3)
Parents’ smoking habits
Past only	5 (17.2)
Current	11 (37.9)
Mother only	4 (13.8)
Father only	6 (20.7)
Both parents	1 (3.4)
Age at onset of first CMA symptoms, mean ± SD, mo	3.6 (4.4)
Time since beginning of the elimination diet, median (min–max; IQR), wk	8.3 (2.0–125.3; 9.7)
Time elapsed between the onset of allergy symptoms and the initiation of the elimination diet, median (min – max; IQR), wk	1.9 (0.1-46.0; 5.7)
Type of first CMA symptoms
Exclusively digestive	10 (34.5)
Exclusively cutaneous	2 (6.9)
Digestive and cutaneous	3 (10.3)
Digestive symptoms and other symptoms such as crying, irritability, abdominal pain, and agitated sleep	5 (17.2)
Digestive symptoms and failure to thrive	6 (20.7)
Digestive, cutaneous and other symptoms such as crying, irritability, and agitated sleep	3 (10.3)
Delay of first CMA symptoms
Immediate	1 (3.4)
Delayed	28 (96.6)
Type of food triggering the first CMA symptoms
Mother’s milk	4 (13.8)
Infant formula	25 (86.2)

SD: Standard deviation; WFA: Weight-for-age; LFA: Length-for-age; WFL: Weight-for-length; BMI: Body mass index; HCA: Head circumference-for-age; CMA: Cow’s milk allergy; IQR: Interquartile range.