Incidence of infectious complications is associated with a high mortality in patients with hepatitis B virus-related acute-on-chronic liver failure

Table 5 Correlation of grades of acute-on-chronic liver failure and liver failure scores with bacterial and/or fungal infections

	Total, n	Infection, n(%)	No infection n (%)	Corelation coefficient	Sig	χ2	P-value
ACLF grade	174	114	60	0.365	0.000	26.697	0.000
ACLF-1	41	15 (36.59)	26 (63.41)
ACLF-2	51	31 (60.78)	20 (39.22)
ACLF-3	82	68 (82.93)	14 (17.07)
MELD	174	114	60	0.285	0.001	15.421	0.001
< 20	87	46 (52.87)	41 (47.13)
20-29	62	45 (72.58)	17 (27.42)
30-39	21	19 (90.48)	2 (9.52)
≥ 40	4	4 (100)	0
MELD-Na	174	114	60	0.294	0.001	16.475	0.001
< 25	121	69 (57.02)	52 (42.98)
25-34	31	23 (74.19)	8 (25.81)
35-44	17	17 (100)	0
≥ 45	5	5 (100)	0
iMELD	174	114	60	0.368	0.000	27.181	0.000
< 30	32	15 (46.88)	17 (53.12)
30-39	74	39 (52.7)	35 (47.3)
40-49	41	34 (82.93)	7 (17.07)
50-59	20	19 (95)	1 (5)
≥ 60	7	7 (100)	0
ALBI	174	114	60	0.215	0.015	8.454	0.015
≤ -2.60	4	1 (25)	3 (75)
-2.60~-1.39	49	26 (53.06)	23 (46.94)
> -1.39	121	87 (71.9)	34 (28.1)
CTP	174	114	60	0.257	0.000	12.301	0.000
5-9	33	13 (39.4)	20 (60.6)
≥ 10	141	101 (71.63)	40 (28.37)

CTP: Child-Turcotte-Pugh; MELD: Model for End-Stage Liver Disease; MELD-Na: MELD-sodium; iMELD: Integrated MELD; ALBI: Albumin-bilirubin; ACLF grade: Acute-on-chronic liver failure grade; ACLF-1: Acute-on-chronic liver failure grade 1; ACLF-2: Acute-on-chronic liver failure grade 2; ACLF-3: Acute-on-chronic liver failure grade 3.