Performance of common imaging techniques vs serum biomarkers in assessing fibrosis in patients with chronic hepatitis B: A systematic review and meta-analysis

Table 4 Subgroup analysis of sample size in prediction of significant fibrosis

Diagnostic test	Sample size	Number of studies (N)	AUSROC (95%CI)	SEN (95%CI)	SPE (95%CI)
APRI	n < 100	8 (588)	0.73 (0.69-0.77)	0.67 (0.60-0.74)	0.68 (0.61-0.75)
	100 ≤ n < 300	27 (5286)	0.77 (0.73-0.80)	0.69 (0.62-0.76)	0.72 (0.65-0.78)
	n ≥ 300	12 (7851)	0.73 (0.69-0.77)	0.67 (0.57-0.76)	0.69 (0.58-0.78)
FIB-4	n < 100	6 (411)	0.77 (0.73-0.80)	0.64 (0.54-0.73)	0.77 (0.67-0.85)
	100 ≤ n < 300	14 (2917)	0.76 (0.72-0.80)	0.62 (0.53-0.71)	0.77 (0.69-0.83)
	n ≥ 300	12 (7851)	0.74 (0.70-0.77)	0.62 (0.53-0.69)	0.74 (0.67-0.79)
ARFI	n < 100	2 (173)	0.72/0.75	0.83/0.50	0.65/0.90
	100 ≤ n < 300	9 (1354)	0.90 (0.87-0.92)	0.78 (0.71-0.84)	0.88 (0.82-0.93)
	n ≥ 300	0	-	-	-
Fibroscan	n < 100	6 (445)	0.80 (0.76-0.83)	0.70 (0.57-0.80)	0.76 (0.68-0.83)
	100 ≤ n < 300	20 (3659)	0.84 (0.81-0.87)	0.74 (0.69-0.79)	0.83 (0.77-0.87)
	n ≥ 300a	3 (931)	0.82 (0.69-0.95)	0.62 (0.57-0.66)	0.88 (0.84-0.90)

^a The results were calculated with Meta-Disc software (v. 1.4). SEN: Sensitivity; SPE: Specificity; CI: Confidence interval; AUSROC: The area under the summary receiver operating characteristic curve; APRI: Aminotransferase-to-platelet ratio index; FIB-4: Fibrosis index based on the 4 factors; ARFI: Acoustic radiation force impulse.