Copyright
©The Author(s) 2019.
World J Clin Cases. Aug 6, 2019; 7(15): 1937-1953
Published online Aug 6, 2019. doi: 10.12998/wjcc.v7.i15.1937
Published online Aug 6, 2019. doi: 10.12998/wjcc.v7.i15.1937
Table 4 Genomic assays to predict outcome in neoadjuvant endocrine therapy
Genomic assay | Gene number | Genomic information | Method | Current results in NAE | Ref. |
Oncotype DX® | 21 (16+5) | Proliferative-related genes: Ki67 AURKA, BIRC5, CCNB1, MYBL2 | QRT-PCR | Recurrence score; low RS results imply a greater likelihood of response to NAE | [62-63] |
Invasive-related genes: MMP11, CTSL2 | |||||
Estrogen-related genes: ESR1, PGR, BCL2, SCUBE2 | |||||
HER2-related genes: ERBB2, GRB7 | |||||
Other genes: GSTM1, CD68, BAG1 | |||||
Reference genes: ACTB, GAPDH, RPLPO, GUS, TFRC | |||||
EndoPredict (EP) | 12 (8+4) | Proliferative-related genes: BIRC5, UBE2C, DHCR7 | QRT-PCR | Lower genomic risk related to favorable response. | [69] |
Estrogen-related genes: RBBP8, IL6ST, AZGP1, MGP, STC2 | |||||
Reference genes: CALM1, OAZ1, RPL37A, HBB | |||||
MammaPrint (and BluepPrint) | 70 | AA555029_RC, ALDH4A1, AP2B1, AYTL2, BBC3, C16orf61, C20orf46, C9orf30, CCNE2, CDC42BPA, CDCA7, CENPA, COL4A2, DCK, DIAPH3, DTL, EBF4, ECT2, EGLN1, ESM1, EXT1, etc. | Microarray analysis | Distinguish breast cancer subtypes; luminal-subtype patients have a promising prognosis | [73] |
Four-gene predictive model | 4 | Proliferative-related genes: ASPM and MCM4 | QRT-PCR or IHC | Associated to RFS and BCS | [75] |
Immune-related gene: IL6ST | |||||
Apoptosis induction-related gene: NGFRAP1 |
- Citation: Yao LT, Wang MZ, Wang MS, Yu XT, Guo JY, Sun T, Li XY, Xu YY. Neoadjuvant endocrine therapy: A potential strategy for ER-positive breast cancer. World J Clin Cases 2019; 7(15): 1937-1953
- URL: https://www.wjgnet.com/2307-8960/full/v7/i15/1937.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v7.i15.1937