Cost-analysis of inpatient and outpatient parenteral antimicrobial therapy in orthopaedics: A systematic literature review

Table 5 Daily costs calculated in Euro for inpatient parenteral antibiotic therapy and outpatient parenteral antibiotic therapy (exchange rate based on mid of publication year)

ID	First author	Year	Ref.	IPAT		OPAT
				€ per case	€ per day	€ per case	€ per day
1	Al Alawi	2015	[8]		143.361		57.351
2	Antoniskis	1978	[9]		251.26		74.09
3	Bernand	2001	[10]		755.88		137.34
4	Chapman	2009	[11]	-	418.92		170.71
5	Connors	2017	[12]	2550.69		1621.42
6	Gonzales	2017	[13]	4357	519	2350	98
7	Gray	2012	[14]
8	Grizzard	1991	[15]		110.29		77.89
9	Harrison	2015	[16]		337.26		140.53
10	Heintz	2011	[17]		492.12		28.38
11	Kieran	2009	[18]				168
12	Lacroix	2014	[19]		1125		228
13	Malone	2015	[20]		68524
14	Nathwani	2003	[21]	17502.42	460.59	2685.24
15	Nguyen	2010	[22]		823.73		268.76
16	Ruh	2015	[23]
17	Seaton	2014	[24]	15670.97		7863.77
18	Sims	2013	[25]	17881.4	308.3	1716.61	29.6
19	Theocharis	2012	[26]		180	637	164
20	Wai	2000	[27]	20278		9188
21	Yong	2009	[28]	8873.23	326.94	9111.46	198.88

¹Calculation simplified based on limited data. Calculations not applicable for two studies. IPAT: Inpatient parenteral antibiotic therapy; OPAT: Outpatient parenteral antibiotic therapy.