Cost-analysis of inpatient and outpatient parenteral antimicrobial therapy in orthopaedics: A systematic literature review

Table 3 Details of included studies

ID	First author	Ref.	Year	Country	Design	Diagnosis	Cases/Patients (n)	Antibiotic agent
1	Al Alawi	[8]	2015	Bahrain	Retrospective	Bacterial tonsillitis	97	Ceftriaxon
2	Antoniskis	[9]	1978	United States	Retrospective	Endocarditis + Osteomyelitis	13/7 (Controls)	Multiple
3	Bernard	[10]	2001	Switzerland	Prospective	Osteomyelitis (incl. 10 PPJI)	39	Multiple
4	Chapman	[11]	2009	United Kingdom	Retrospective	multiple	334/296	Multiple
5	Connors	[12]	2017	Canada	Prospective	Dental	110/.	Multiple
6	Gonzales	[13]	2017	Spain	Retrospective	Multiple	1324/1190	Multiple
7	Gray	[14]	2012	United Kingdom	Retrospective	Multiple	291/.	Multiple
8	Grizzard	[15]	1991	United States	Retrospective	Multiple	46/.	Multiple
9	Harrison	[16]	2015	United Kingdom	Retrospective	Kidney transplant	12/9	n. a.
10	Heintz	[17]	2011	United States	Prospective	Multiple	569/536	Multiple
11	Kieran	[18]	2009	Ireland	Retrospective	Multiple	60/56	Multiple
12	Lacroix	[19]	2014	France	Retrospective	Endocarditis	18/.	Multiple
13	Malone	[20]	2015	Australia	Retrospective	Diabetic foot	59/.	n. a.
14	Nathwani	[21]	2003	United Kingdom	Retrospective	Bone and joint	55/.	Teicoplanin
15	Nguyen	[22]	2010	United States	NA	Cellulitis	80/.	Multiple
16	Ruh	[23]	2015	United States	Retrospective	Multiple	96/85	Multiple
17	Seaton	[24]	2014	United Kingdom	Retrospective	MRSA skin and soft tissue	173/.	Multiple
18	Sims	[25]	2013	United Kingdom	Retrospective	PPJI	96/85	Multiple
19	Theocharis	[26]	2012	Greece	Retrospective	Multiple	173/.	Multiple
20	Wai	[27]	2000	Canada	Retrospective	Multiple	80/.	Multiple
21	Yong	[28]	2009	Singapore	Retrospective	Multiple	96/85	Multiple

OPAT: Outpatient parenteral antibiotic therapy; PPJI: Periprosthetic joint infections.