Diagnostic-therapeutic management of bile duct cancer

Table 3 Eighth edition of the TNM classification of the AJCC/UICC (2017-2018)[30] - Distal cholangiocarcinoma

Primary tumor (pT)	Regional lymph nodes (pN)	Distant metastasis (pM)	Stage grouping
TX: Primary tumor cannot be assessed	NX: Regional lymph nodes cannot be assessed		Stage 0: Tis N0 M0; Stage I: T1 N0 M0; Stage IIA: T1 N1 M0 or T2 N0 M0; Stage IIB: T2 N1 M0 or T3 N0-1 M0; Stage IIIA: T1-3 N2 M0; Stage IIIB: T4 N0-2 M0
T0: No evidence of primary tumor	N0: No regional lymph node metastasis	M0: No distant metastasis
Tis: Carcinoma in situ / high grade dysplasia
T1: tumor invades the bile duct wall with a depth less than 5 mm	N1: Metastasis in one to three regional lymph nodes	M1: Distant metástasis
T2: Tumor invades the bile duct wall with a depth of 5 - 12 mm	N2: Metastasis in four or more regional lymph nodes
T3: Tumor invades the bile duct wall with a depth greater than 12 mm
T4: Tumor invades the celiac axis, superior mesenteric artery or common hepatic artery