Anti-hepatitis C virus therapy in chronic kidney disease patients improves long-term renal and patient survivals

Table 4 Sensitivity analysis of adjusted hazard ratios for end-stage renal disease and death between the untreated and uninfected chronic kidney disease patients as well as between the treated and untreated chronic kidney disease patients

	Adjusted HR for ESRD1			Adjusted HR for death2
	HR	95%CI	P value	HR	95%CI	P value
Propensity score-matched CKD patients
Uninfected cohort (n = 3856)	1.00	Reference		1.00	Reference
Untreated HCV-infected cohort (n = 1928)	1.28	1.03-1.61	0.028	1.31	1.18-1.45	< 0.001
Propensity score-matched CKD patients
Untreated HCV-infected cohort (n = 1928)	1.00	Reference		1.00	Reference
Treated HCV-infected cohort (n = 482)	0.28	0.11-0.71	0.007	0.71	0.54-0.92	0.011

¹Adjusted for all covariates (age per year, sex, comorbidity, ACEI/ARB, enrollee category, number of medical visits, and Charlson comorbidity index score) and competing mortality;

²Adjusted for all covariates (age per year, sex, comorbidity, ACEI/ARB, enrollee category, number of medical visits, and Charlson comorbidity index score). CKD: Chronic kidney disease; CI: Confidence interval; ACEI/ARB: Angiotensin converting enzyme inhibitor/angiotensin receptor blocker; ESRD: End-stage renal disease; HCV: Hepatitis C virus.