Antiviral effects of hepatitis B virus S gene-specific anti-gene locked nucleic acid in transgenic mice

doi:10.12998/wjcc.v6.i8.183

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Aug 16, 2018; 6(8): 183-191
Published online Aug 16, 2018. doi: 10.12998/wjcc.v6.i8.183

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Figure 1 Inhibition of hepatitis B virus deoxyribonucleic acid and hepatitis B surface antigen by anti-gene-locked nucleic acid, anti-sense-locked nucleic acid, and lamivudine. A: The inhibition rate of HBsAg; B: The inhibition rate of hepatitis B virus (HBV) deoxyribonucleic acid. ^aSignificant (P < 0.05) HBsAg and HBV DNA expression alterations between lamivudine, anti-sense-LNA vs anti-gene-LNA. Values are mean ± SD. LNA: Locked nucleic acid; HBsAg: HBV surface antigen.

Citation: Xiao SR, Xu GD, Wei WJ, Peng B, Deng YB. Antiviral effects of hepatitis B virus S gene-specific anti-gene locked nucleic acid in transgenic mice. World J Clin Cases 2018; 6(8): 183-191
URL: https://www.wjgnet.com/2307-8960/full/v6/i8/183.htm
DOI: https://dx.doi.org/10.12998/wjcc.v6.i8.183