Prognostic role of alpha-fetoprotein response after hepatocellular carcinoma resection

Table 3 Univariate and multivariate analysis of factors associated with overall survival

	Univariate		Multivariate
	HR (95%CI)	P value	HR (95%CI)	P value
Gender
Male	1
Female	1.083 (0.62-1.88)	0.775
Age (yr)	0.998 (0.97-1.02)	0.905
HBV
No	1
Yes	1.032 (0.59-1.79)	0.909
HCV
No	1
Yes	1.154 (0.56-2.37)	0.696
Platelet × 103	1.002 (0.99-1.00)	0.117
Tumor size (cm)	1.062 (0.99-1.13)	0.066
No. of tumor
Single	1		1
Multiple	2.240 (1.27-3.94)	0.005	1.991 (1.12-3.52)	0.018
mVI
No	1		1
Yes	3.324 (1.85-5.95)	0	3.240 (1.77-5.90)	0
Stage
Stage I	1
Stage II or higher	1.941 (1.11-3.38)	0.019
Resection margin
Free margin	1
Positive margin	2.544 (1.00-6.47)	0.05
Anti-viral treatment
No	1
Yes	0.786 (0.45-1.36)	0.392
Recurrence
No	1
Yes	7.917 (3.56-17.56)	0
AFP
Normal group	1		1
Response group	1.338 (0.74-2.41)	0.334	1.168 (0.64-2.12)	0.612
Non-response group	3.635 (1.61-8.18)	0.002	3.621 (1.59-8.21)	0.002

AFP: Alpha-fetoprotein; HBV: Hepatitis B virus; HCV: Hepatitis C virus.