High prevalence of cholestasis, with increased conjugated bile acids in inflammatory bowel diseases patients

doi:10.12998/wjcc.v6.i4.44

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Clin Cases. Apr 16, 2018; 6(4): 44-53
Published online Apr 16, 2018. doi: 10.12998/wjcc.v6.i4.44

Table 4 Bile acids subtypes

	TBA > 8 (80)	TBA < 8 (80)	P value
TBA	14.64 (1.24)	3.31 (0.22)	1.07 × 10^-15
Primary
CA	1.09 (0.29)	0.29 (0.04)	0.008
Cholic acid	1.09 (0.29)	0.29 (0.04)	0.008
CDC chenodeoxycholate	2.06 (0.41)	0.68 (0.13)	0.002
Secondary
DC	1.35 (0.27)	0.28 (0.04)	0.000
deoxycholate	1.35 (0.27)	0.28 (0.04)	0.000
LCA	0.07 (0.01)	0.07 (0.01)	0.9
lithocholic acid	0.07 (0.01)	0.07 (0.01)	0.9
Tertiary
UDC	0.34 (0.05)	0.14 (0.03)	0.000
ursodeoxycholate	0.34 (0.05)	0.14 (0.03)	0.000
Primary conjugated
TC	0.37 (0.08)	0.04 (0.01)	0.000
taurocholate	0.37 (0.08)	0.04 (0.01)	0.000
GCA	1.78 (0.28)	0.38 (0.05)	1.83 × 10^-6
gylcocholate acid	1.78 (0.28)	0.38 (0.05)	1.83 × 10^-6
TCDC	0.74 (0.11)	0.18 (0.02)	1.58 × 10^-6
taurochenodeoxycholate	0.74 (0.11)	0.18 (0.02)	1.58 × 10^-6
GCDC	4.72 (0.33)	1.42 (0.12)	1.54 × 10^-16
glycochenodeoxycholate	4.72 (0.33)	1.42 (0.12)	1.54 × 10^-16
Secondary conjugated
GDC	1.01 (0.10)	0.30 (0.04)	1.38 × 10^-9
glycodeoxycholate	1.01 (0.10)	0.30 (0.04)	1.38 × 10^-9
TDC	0.20 (0.03)	0.05 (0.01)	8.78 × 10^-7
taurodeoxycholate	0.20 (0.03)	0.05 (0.01)	8.78 × 10^-7
TLC	0.04 (0.01)	0.01 (0.00)	8.46 × 10^-5
taurolithocholate	0.04 (0.01)	0.01 (0.00)	8.46 × 10^-5
GLC	0.09 (0.01)	0.09 (0.01)	0.646
glycolithocholate	0.09 (0.01)	0.09 (0.01)	0.646
Tertiary conjugated
TUDC	0.06 (0.01)	0.001 (0.00)	1.69 × 10^-8
tauroursodeoxycholate	0.06 (0.01)	0.001 (0.00)	1.69 × 10^-8
GUDC	0.84 (0.12)	0.19 (0.03)	4.58 × 10^-7
glycoursodeoxycholate	0.84 (0.12)	0.19 (0.03)	4.58 × 10^-7
Hydroxydes
DHCA	0.004 (0.002)	0.001 (0.001)	0.291
dihydroxycholestanoic acid	0.004 (0.002)	0.001 (0.001)	0.291
THCA	0.001 (0.001)	0.000 (0.000)	0.275
trihydroxycholestanoic acid	0.001 (0.001)	0.000 (0.000)	0.275
Ratio
Primary/secondary	3.48 (0.92)	4.42 (1.34)	0.566
Primary/TBA	0.23 (0.05)	0.31 (0.04)	0.211
Conjugated glycine/taurine
Primary	11.64 (1.18)	10.70 (0.89)	0.537
Secondary	6.40 (0.61)	5.15 (0.66)	0.209

Bile acids subtypes expressed in μmol/L with standard deviation under bracket, in 80 patients with a total bile acids level of more than 8 μmol/L compared with 80 patients with a total bile acids level of less than 8 μmol/L. TBA: Total bile acids; CA: Cholic acid; CDC: Chenodeoxycholate; DC: Deoxycholate; LCA: Lithocholic acid; UDC: Ursodeoxycholate; TC: Taurocholate; GCA: Gylcocholate acid; TCDC: Taurochenodeoxycholate; GCDC: Glycochenodeoxycholate; TDC: Taurodeoxycholate; GDC: Glycodeoxycholate; TLC: Taurolithocholate; GLC: Glycolithocholate; TUDC: Tauroursodeoxycholate; GUDC: Glycoursodeoxycholate; DHCA: Dihydroxycholestanoic acid; THCA: Trihydroxycholestanoic acid.

Citation: Girardin M, Hadengue A, Frossard JL, the Swiss IBD Cohort Study Group. High prevalence of cholestasis, with increased conjugated bile acids in inflammatory bowel diseases patients. World J Clin Cases 2018; 6(4): 44-53
URL: https://www.wjgnet.com/2307-8960/full/v6/i4/44.htm
DOI: https://dx.doi.org/10.12998/wjcc.v6.i4.44