Safety of applying midazolam-ketamine-propofol sedation combination under the supervision of endoscopy nurse with patient-controlled analgesia pump in colonoscopy

Table 3 Hemodynamic changes during the procedure

		Endoscopy Nurse		Anaesthetist		P1
		mean ± SD	Median	mean ± SD	Median
Pulse (beats per minute)	Baseline	82.8 ± 13.3	82.5	84.2 ± 11.7	85.5	0.673
	1st min	81.4 ± 13.3	79.0	85.7 ± 14.6	84.0	0.251
	2nd min	80.9 ± 13.8	79.0	83.5 ± 17.9	81.0	0.716
	3rd min	80.8 ± 13.5	79.0	80.7 ± 19.2	79.5	0.704
	4th min	81.0 ± 15.3	80.0	80.1 ± 18.5	77.5	0.665
	5th min	81.9 ± 14.6	81.0	80.5 ± 18.8	78.0	0.414
	≥ 8th min	81.1 ± 14.7	78.5	77.5 ± 14.4	75.0	0.336
Systolic blood pressure (mmHg)	Baseline	131.0 ± 20.5	131.5	136.1 ± 22.3	135.0	0.412
	1st min	126.2 ± 17.6	121.0	129.9 ± 19.4	132.5	0.579
	2nd min	124.2 ± 13.6	125.0	125.7 ± 29.5	121.5	0.519
	3rd min	123.4 ± 13.9	122.0	126.5 ± 27.9	123.0	0.952
	4th min	126.5 ± 15.9	125.0	131.8 ± 30.3	129.5	0.448
	5th min	123.8 ± 13.4	122.0	139.3 ± 28.7	141.0	0.014
	≥ 8th min	124.1 ± 17.2	120.5	142.3 ± 26.7	141.0	0.003
Diastolic blood pressure (mmHg)	Baseline	73.2 ± 12.3	70.5	73.4 ± 13.4	74.0	0.871
	1st min	70.6 ± 10.2	69.5	74.7 ± 14.0	74.0	0.183
	2nd min	71.1 ± 11.1	71.0	72.9 ± 18.3	69.0	0.988
	3rd min	71.2 ± 11.1	70.0	76.3 ± 18.2	75.5	0.359
	4th min	72.8 ± 11.1	72.0	78.7 ± 17.9	80.5	0.175
	5th min	69.2 ± 11.5	69.5	81.9 ± 17.2	82.0	0.002
	≥ 8th min	73.2 ± 11.8	70.5	83.4 ± 16.8	82.0	0.005
SpO2	Baseline	96.7 ± 1.9	97.0	94.4 ± 2.7	94.0	0.000
	1st min	96.0 ± 2.8	97.0	94.7 ± 2.4	95.0	0.014
	2nd min	96.5 ± 3.5	97.0	95.3 ± 2.2	95.5	0.071
	3rd min	96.2 ± 2.8	97.0	95.9 ± 2.0	95.5	0.307
	4th min	96.4 ± 2.3	97.0	96.3 ± 1.9	96.0	0.502
	5th min	95.1 ± 5.3	97.0	96.1 ± 1.7	96.0	0.685
	≥ 8th min	96.1 ± 2.3	97.0	96.0 ± 1.4	96.0	0.422

¹Mann-Whitney U test.