Safety of fecal microbiota transplantation in Chinese children: A single-center retrospective study

Table 1 Patient and donor characteristics

	Item	Results
Patients	Total number of study patients	49
	Gender, male n (%)	27 (55.1)
	Age [mean ± SD (range), mo]	68.16 ± 53.09 (4-193)
	Follow-up duration [mean ± SD (range), mo]	23.14 ± 15.32 (1-55)
	Disease type
	Gastrointestinal disorder
	CDI1	33
	Chronic intractable diarrhea (without CD evidence)2	6
	Functional gastrointestinal disorder	1
	Nongastrointestinal disorder
	Metabolic syndrome	1
	NASH	2
	Eczema	2
	Others3	4
	Patients with single vs multiple FMTs
	Single	20
	Multiple (range of FMT rounds)	29 (2-11 rounds)
	Immunodeficiency	15
Donors	Total number	30
	Gender, male n (%)	11 (36.7)
	Age [mean ± SD (range), yr]	32.77 ± 8.266 (2-49)
	Relative genetic background, n (%)	46.7 (14)

¹CDI is Clostridium difficile infection in two primary immunodeficiency patients (VEO-IBD with IL10Ra gene mutation and IPEX with FOXP3 gene mutation), nine IBD patients on immunosuppressive agents and 18 recurrent CDI patients;

²Chronic intractable diarrhea without CD evidence in four primary immunodeficiency patients (one DNA ligase IV syndrome with LIG4 gene mutation and three undetermined immunodeficiency) and two cases of antibiotic-associated diarrhea;

³Other diseases include one case of systemic juvenile rheumatoid arthritis, two cases of hemophagocytic lymphohistiocytosis with Epstein-Barr virus infection and one case of Okuda syndrome with severe constipation. NASH: Non-alcoholic steatohepatitis; FMT: Fecal microbiota transplantation; IBD: Inflammatory bowel disease.