Inflammation and de-differentiation in pancreatic carcinogenesis

doi:10.12998/wjcc.v6.i15.882

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Dec 6, 2018; 6(15): 882-891
Published online Dec 6, 2018. doi: 10.12998/wjcc.v6.i15.882

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Figure 3 Pancreatic cell de-differentiation, inflammation, and carcinogenesis. Carcinogenesis is promoted by reprogramming factors (Oct3/4, Sox2, Klf4, and c-Myc). When the reprogramming factors are activated, acinar cell-related genes are suppressed. Pancreatitis also shows such transcriptional changes.

Citation: Seimiya T, Otsuka M, Iwata T, Tanaka E, Suzuki T, Sekiba K, Yamagami M, Ishibashi R, Koike K. Inflammation and de-differentiation in pancreatic carcinogenesis. World J Clin Cases 2018; 6(15): 882-891
URL: https://www.wjgnet.com/2307-8960/full/v6/i15/882.htm
DOI: https://dx.doi.org/10.12998/wjcc.v6.i15.882