Scoring systems for prediction of mortality in decompensated liver cirrhosis: A meta-analysis of test accuracy

Table 2 Results of subgroup analysis of Child-Turcotte-Pugh, Model for End-stage Liver Disease score, and Model for End-stage Liver Disease-Na score in predicting mortality at different time points

End-point (mortality)	Number of studies	Sensitivity (95%CI)	Specificity (95%CI)	Positive (95%CI)	Negative (95%CI)	DOR (95%CI)	I2	AUROC
CTP
< 3 mo	8	0.72 (0.61, 0.81)	0.73 (0.65, 0.79)	2.6 (1.9, 3.7)	0.39 (0.26, 0.58)	7 (3, 14)	0	0.78
3 mo	5	0.79 (0.60, 0.91)	0.79 (0.59, 0.90)	3.7 (1.8, 7.6)	0.26 (0.13, 0.55)	14 (4, 46)	96	0.86
6 mo	3	0.90 (0.80, 0.96)	0.69 (0.64, 0.75)	3.0 (2.1, 4.5)	0.16 (0.08, 0.33)	18 (8, 40)	0	0.91
12 mo	3	0.68 (0.58, 0.72)	0.68 (0.64, 0.72)	3.3 (1.5, 7.3)	0.49 (0.40, 0.60)	7 (3, 20)	84	0.72
MELD
< 3 mo	9	0.66 (0.59, 0.73)	0.87 (0.81, 0.91)	5.1 (3.4, 7.7)	0.39 (0.31, 0.48)	13 (7, 24)	6	0.76
3 mo	6	0.70 (0.60, 0.78)	0.78 (0.65, 0.87)	3.1 (2.0, 4.9)	0.39 (0.29, 0.52)	8 (4, 15)	95	0.78
6 mo	3	0.74 (0.65, 0.82)	0.83 (0.79, 0.87)	4.4 (2.4, 8.2)	0.30 (0.23, 0.43)	15 (7, 34)	56	0.83
12 mo	4	0.60 (0.51, 0.68)	0.88 (0.79, 0.93)	4.8 (3.0, 7.7)	0.46 (0.39, 0.55)	10 (6, 17)	92	0.75
MELD-Na
< 3 mo	4	0.82 (0.69, 0.91)	0.82 (0.64, 0.92)	4.6 (2.2, 9.8)	0.21 (0.12, 0.37)	22 (9, 53)	89	0.89
3 mo	4	0.75 (0.63, 0.84)	0.84 (0.80, 0.87)	4.6 (3.5, 6.0)	0.30 (0.20, 0.46)	15 (8, 30)	0	0.86
6 mo	3	0.82 (0.73, 0.88)	0.85 (0.80, 0.88)	5.3 (3.7, 7.7)	0.22 (0.15, 0.32)	25 (14, 43)	0	0.90
12 mo	3	0.72 (0.63, 0.76)	0.83 (0.80, 0.86)	4.2 (3.4, 5.1)	0.37 (0.30, 0.45)	12 (8, 18)	0	0.84

CTP: Child-Turcotte-Pugh; MELD: Model for End-stage Liver Disease score; DOR: Diagnostic odd ratio; AUROC: Area under the summary receiver operating characteristic curve.