Genetic associations of inflammatory bowel disease in a South Asian population

Table 3 Associations of variants with Crohn’s disease and ulcerative colitis

SNPs	Candidate gene	Associated subtype	Heterogenous		Homogenous
			odds ratio1	P	odds ratio1	P
rs10045431	IL 12B	CD	0.579	0.027	2.491	0.178
rs11805303	IL23R	CD	0.909	0.609	1.505	0.010
rs12612347	ARPC2	UC	0.896	0.479	0.991	0.957
rs13361189	IRGM	CD	1.093	0.578	1.355	0.331
rs1558744	IFN-c, IL26, IL22	UC	1.043	0.811	5.560	0.036
rs1728785	CDH1	UC	0.829	0.244	1.410	0.314
rs3024505	IL10	UC	1.194	0.351	2.446	0.244
rs3737240	FCGR2A	UC	1.182	0.291	1.187	0.564
rs4613763	PTGER4	CD	2.325	0.273	2	-
rs5771069	IL17REL/PIM3	UC	0.915	0.589	0.599	0.109
rs6017342	HNF4a, SERINC3	UC	0.690	0.021	0.920	0.746
rs744166	STAT3	CD	0.841	0.266	0.900	0.541
rs7809799	SMURF1	UC	1.149	0.542	2.747	0.270
rs8867743	LAMB1	UC	1.163	0.330	1.494	0.001
rs9268853	HLA DRB5	UC	0.684	0.017	1.049	0.850
rs9822268	APEH	UC	0.748	0.748	1.116	0.779

¹Odds ratios when comparing patients with healthy controls;

²No heterozygous individuals were present in this study population;

³Significantly associated with the relevant phenotype after Bonferroni correction. SNPs: Single nucleotide polymorphisms; CD: Crohn’s disease; UC: Ulcerative colitis.