Genetic associations of inflammatory bowel disease in a South Asian population

Table 1 Characteristics of the patient population, n (%)

Characteristic	CD (n = 153)	UC (n = 258)	P1
Male gender	77 (50.3)	123 (47.7)	0.80
Age in years (mean, SD)	41.0 (16.9)	47.6 (14.9)	< 0.01
Race
Sinhala	129 (84.31)	229 (88.75)
Tamil	11 (7.19)	13 (5.06)
Muslim	11 (7.19)	13 (5.03)
Other	2 (1.31)	3 (1.17)
Body mass index mg/m2 (mean, SD)	21.4 (4.6)	22.9 (4.5)	< 0.01
Family history of IBD	7 (4.6)	12 (4.7)	0.98
Comorbidities
Diabetes	11 (7.1)	41 (15.9)	0.01
Hypertension	16 (10.5)	37 (14.3)	0.26
BA/COPD	9 (5.8)	22 (8.5)	0.33
Tuberculosis	7 (4.6)	1 (0.4)	< 0.01
Tobacco smoking	25 (16.3)	49 (18.9)	0.39
Disease characteristics
Duration of the disease (yr)	4.8 (4.2)	7.3 (5.7)	< 0.01
Extensive disease in UC	76 (29.5)	-	-
Upper GI disease in CD	11 (7.2)	-	-
Severe/complicated disease	47 (30.7)	130 (50.4)	< 0.01
Maintained remission	142 (92.9)	245 (95.0)	0.83
Treatment refractory disease	24 (15.68)	24 (9.3)	< 0.05
Use of biologics	16 (10.5)	7 (2.7)	< 0.01

¹Unadjusted univariate P value. IBD: Inflammatory bowel disease; CD: Crohn's disease; UC: Ulcerative colitis; GI: Gastrointestinal; BA: Bronchial asthma; COPD: Chronic obstructive pulmonary disease.