Copyright
©The Author(s) 2018.
World J Clin Cases. Dec 6, 2018; 6(15): 869-881
Published online Dec 6, 2018. doi: 10.12998/wjcc.v6.i15.869
Published online Dec 6, 2018. doi: 10.12998/wjcc.v6.i15.869
Table 2 Examples of epigenetic biomarkers for colorectal cancer
Epigenetic markers | |
Methylated genes/loci | |
p14 ARF, p15 INK 4b, p16 INK4a | Cell cycle regulation |
hMLH1, MGMT | DNA repair system; progression from adenoma to cancer |
DAPK | Apoptosis |
THBS1 | Angiogenesis inhibition |
SPARC | Lymphovascular invasion, metastasis |
TIMP3 | Metastasis suppression |
CDH1, CDH13 | Cell adherence |
Methylation biomarkers | |
VIM, SEPT9, SFRP2 | Biomarkers for CRC and as DNA-based colon cancer screening tests |
TWIST1, IGFBP3, GAS7, ALX4, SDC2 | Higher methylation levels in CRC compared to normal subjects (promising diagnostic biomarkers) |
Candidate biomarkers | |
Methylated UGT1A1 | Affects irinotecan treatment (in vitro) |
Methylated DYPD, UMPK, and SPARC | Affect 5-FU treatment (in vitro) |
TFAP2E | No responsiveness to oxaliplatin, irinotecan, and 5-FU |
- Citation: Vacante M, Borzì AM, Basile F, Biondi A. Biomarkers in colorectal cancer: Current clinical utility and future perspectives. World J Clin Cases 2018; 6(15): 869-881
- URL: https://www.wjgnet.com/2307-8960/full/v6/i15/869.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v6.i15.869