Safety of laparoscopic surgery in digestive diseases with special reference to antithrombotic therapy: A systematic review of the literature

Table 2 Reported data concerning bleeding complications of "advanced" abdominal surgery in patients with antithrombotic therapy (antiplatelet therapy and/or anticoagulation therapy)

First author of the reports	Year	Surgery type	Drug use and exposure	Bleeding events	TE, mortality
Laparoscopic liver resection
Fujikawa[24]	2017	Laparoscopic liver resection vs open liver resection	Patients with ATT (n = 100)	SBL ≥ 500 mL 23% in those with ATT vs 27% in control (P = 0.468)	TE 1% in ATT vs 1.3% in control (P = 0.310)
			Patients without ATT (control, n = 158)	PBC 4.6% in those with ATT vs 4.3% in control	Mortality 1% in ATT vs 0% in control (P = 0.350)
Laparoscopic colorectal cancer resection
Ono[12]	2013	Laparoscopic colorectal cancer resection (n = 218) or laparoscopic cholecystectomy (n = 270)	Patients with continued ASA (n = 52)	SBL 27 mL in continued ASA vs 17 mL in control (P = 0.430)	No mortality in both groups
			Patients without ASA (control, n = 436)
Shimoike[21]	2016	Colorectal cancer surgery including laparoscopic surgery (n = 191)	Patients with APT (n = 148)	PBC 0.7% in those with APT vs 0.9% in control (P = 1.000)	TE 0.7% in APT vs 0% in control (P = 0.301)
			Patients without APT (control, n = 343)		No mortality in both groups
Laparoscopic gastrectomy
Takahashi[22]	2017	Laparoscopic gastrectomy	Patients with ATT (continued in high risk, n = 12)	No difference in SBL or PBC between the groups	No difference in overall complications between the groups
			Patients without ATT (n = 34)		No mortality in both groups
Gerin[23]	2015	Laparoscopic sleeve gastrectomy	Patients with ACT (n = 15)	PBC 6.7% in ACT vs 3.3% in control (P = 0.60)	No mortality in both groups
			Matched patients without ACT (control, n = 30)

ATT: Antithrombotic therapy; APT: Antiplatelet therapy; ACT: Anticoagulation therapy; TE: Thromboembolism; SBL: Surgical blood loss; PBC: Postoperative bleeding complications; ASA: Aspirin; HBP: Hepatobiliary and pancreas.