Declining diagnostic accuracy of non-invasive fibrosis tests is associated with elevated alanine aminotransferase in chronic hepatitis B

doi:10.12998/wjcc.v6.i12.521

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Oct 26, 2018; 6(12): 521-530
Published online Oct 26, 2018. doi: 10.12998/wjcc.v6.i12.521

Table 1 Baseline characteristics of the subjects

Characteristics	Total group(n = 599)	ALT ≤ 40 group (n = 272)	40 < ALT ≤ 80group (n = 190)	ALT > 80 group(n = 137)	P-value
Age (yr)	37 (29, 44)	39 (31.25, 46)	37.5 (28, 43.25)	34 (28, 40.5)	< 0.001
Male (%)	349 (58.3)	131 (48.2)	130 (68.4)	88 (64.2)	< 0.001
ALT (U/L)	44 (28, 76)	26 (31, 33)	56 (48, 66)	127 (95, 218.5)	< 0.001
AST (U/L)	32 (24, 48)	24 (20, 28)	36 (31, 42)	70 (55, 115.5)	< 0.001
GGT (U/L)	25 (17, 41)	19 (14, 25)	30 (20, 41.25)	48 (30, 78)	< 0.001
Cholesterol (mmol/L)	4.31 (3.84, 4.96)	4.35 (3.86, 4.95)	4.24 (3.75, 4.95)	4.34 (3.84, 4.99)	0.732
PLT (10⁹/L)	182 (150, 217)	184 (155, 223)	177.5 (145.5, 212)	180 (149, 215)	0.215
INR	1 (1, 1.1)	1 (1, 1.1)	1 (0.99, 1.1)	1 (0.94, 1.1)	0.4
HBV DNA (log₁₀IU/mL)	7.03 (4.24, 8.23)	4.77 (3.32, 7.78)	7.64 (5.72, 8.23)	8.03 (6.81, 8.23)	< 0.001
S (%)
S0	264 (44.1)	128 (47.1)	80 (42.1)	56 (40.9)
S1	147 (24.5)	73 (26.8)	53 (27.9)	21 (15.3)
S2	96 (16)	35 (12.9)	29 (15.3)	32 (23.4)
S3	54 (9)	19 (7.0)	18 (9.5)	17 (12.4)
S4	38 (6.3)	17 (6.3)	10 (5.3)	11 (8.0)
Stage S0-1 fibrosis	411 (68.6)	201 (73.9)	133 (70)	77 (56.2)	0.001
Stage S2-4 fibrosis	188 (31.4)	71 (26.1)	57 (30)	60 (43.8)
APRI	0.53 (0.38,0.86)	0.38 (0.3, 0.49)	0.61 (0.44,0.8)	1.16 (0.88, 1.93)	< 0.001
FIB-4	1.02 (0.72,1.47)	1.02 (0.72,1.37)	0.96 (0.66,1.55)	1.22 (0.82, 1.79)	< 0.001
GPR	0.22 (0.15,0.38)	0.16 (0.11, 0.23)	0.24 (0.17,0.38)	0.42 (0.25, 0.68)	< 0.001
King’s score	6.77 (4.31,11.49)	4.89 (3.54,7.03)	7.18 (4.58,11.58)	13.04 (9.81, 27.15)	< 0.001
Forns index	6.48 (5.44,7.51)	6.33 (5.37,7.37)	6.57 (5.51,7.69)	6.65 (5.57, 7.57)	0.081

Data are expressed as the n (%) or median (interquartile range, IQR). ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transferase; PLT: Platelet; S: Stage of fibrosis; GPR: Gamma-glutamyl transpeptidase (GGT)-to-platelet ratio; APRI: Aspartate aminotransferase (AST)-to-platelet (PLT) ratio index; FIB-4: Fibrosis index based on 4 factors; INR: International sensitivity index.

Citation: Wang L, Fan YX, Dou XG. Declining diagnostic accuracy of non-invasive fibrosis tests is associated with elevated alanine aminotransferase in chronic hepatitis B. World J Clin Cases 2018; 6(12): 521-530
URL: https://www.wjgnet.com/2307-8960/full/v6/i12/521.htm
DOI: https://dx.doi.org/10.12998/wjcc.v6.i12.521