One more chance of fistula healing in inflammatory bowel disease: Stem cell therapy

Table 5 Summary of all clinical trials evaluating stem cell therapy for fistulizing inflammatory bowel disease

Author	Year of study	Fistula site	Study population	Stem cell therapy	Method of administration	Healing type of fistula	Safety	Outcome
Sanz-Baro et al[16]	2015	RV Perianal	5	2 patients with Autologous ASC injected into fistula 3 patients with Allogeneic ASC injected into fistula	All 5 patients treated with either autologous or allogeneic ASCs and achieved remission who became pregnant were given data collection forms assessing age of treatment with ASCs, gestation age, gestational complications, any medication used during pregnancy for CD, type of delivery, fetal weight, and newborn malformations	2 of 5 patients with gestational complications of first term abortions, fetal growth restriction, and small for gestational age 1 of 4 patients who delivered with newborn malformations of syndactyly and clinodactyly	Two of the five patients experienced gestational complications: first trimester miscarriages, fetal growth restriction, and small for gestational age	No evidence that allogeneic or autologous ASC affects fertility in women

CD: Crohn’s disease; RV: Rectovaginal; ASC: Autologous stem cell.