One more chance of fistula healing in inflammatory bowel disease: Stem cell therapy

Table 4 Composite of allogeneic bone marrow derived stem cell therapy trials

Author	Year of study	Fistula site	Study population	Method of administration	Healing type of fistula (unhealed, partially, fully)	Safety	Outcome
Molendijk et al[1]	2015	Perianal	21	Patients assigned to four groups with curettage then intralesional fistula tract injection with stem cells or placebo (1) 1 × 107 (2) 3 × 107 (3) 9 ×107 (4) placebo	Week 24 fistula healing for groups (1) 66.7% (n = 5) (2) 85.7% (n = 5) (3) 28.6% (n = 5) (4) 33.3% (n = 6)	All patients reported pain and pus and/or discharge from fistula for 1 wk postoperatively One patient in each group (1, 2, 3, and placebo) developed perianal abscess	Use of intralesional injections of 3 × 107 was successful in fistula healing.