PNPLA3 rs139051 is associated with phospholipid metabolite profile and hepatic inflammation in nonalcoholic fatty liver disease

Table 4 Phospholipid metabolites correlated with pathological characteristics of nonalcoholic fatty liver disease

Phospholipid metabolites	Steatosis		Lobular inflammation		Ballooning		Fibrosis
	rho	P value	rho	P value	rho	P value	rho	P value
LPC 17:0	0.149	0.399	-0.525	0.001a	0.093	0.599	0.095	0.592
LPC 18:0	0.024	0.892	-0.478	0.004a	0.136	0.442	0.089	0.618
LPC 20:0	-0.071	0.692	-0.585	0.000a	0.010	0.956	0.082	0.645
LPC 20:1	-0.061	0.734	-0.489	0.003a	-0.165	0.352	-0.072	0.686
LPC 20:2	0.092	0.604	-0.453	0.007a	0.145	0.415	0.042	0.812
LPC O-16:0	0.297	0.088	-0.296	0.089	0.025	0.886	0.146	0.410
LPC O-16:1	0.070	0.695	-0.425	0.012a	0.028	0.874	0.027	0.881
LPC O-18:1	-0.114	0.521	-0.407	0.017a	-0.018	0.921	0.107	0.546
LPE 20:4	-0.079	0.658	0.107	0.547	0.071	0.690	-0.071	0.692
LPE 22:6	-0.274	0.117	0.054	0.764	0.125	0.481	0.173	0.327
PC 32:1	0.020	0.913	0.086	0.630	0.107	0.547	-0.069	0.699
PE 34:0	-0.012	0.946	0.193	0.275	-0.173	0.327	-0.146	0.410
PE 34:2	-0.054	0.762	-0.025	0.888	-0.043	0.809	-0.153	0.388
PE 36:2	-0.050	0.777	-0.079	0.659	-0.118	0.506	-0.257	0.143
PE 36:4	-0.091	0.608	0.150	0.398	0.121	0.495	-0.052	0.770
PE 38:4	-0.112	0.529	0.214	0.224	0.110	0.537	-0.065	0.716
PE 38:5	-0.234	0.182	0.178	0.313	-0.026	0.885	-0.096	0.587
PE 38:6	-0.151	0.393	0.096	0.588	0.176	0.320	0.105	0.554
PE 40:5	-0.013	0.944	0.132	0.457	0.049	0.783	-0.194	0.273
PE 40:6	-0.192	0.277	0.132	0.457	0.150	0.397	0.067	0.705
PE O-36:5	0.021	0.905	0.178	0.313	-0.205	0.245	-0.131	0.461

LPC: Lysophosphatidylcholine; LPCO: Lysophosphatidylcholine plasmalogen; LPE: Lysophosphatdylethanolamine; NAFLD: Nonalcoholic fatty liver disease; PC: Phosphatidylcholine; PCO: Choline plasmalogen; PE: Phosphatidylethanolamine; PEO: Ethanolamine plasmalogen; rho: Spearman's rank correlation coefficient. ^aP < 0.05.