PNPLA3 rs139051 is associated with phospholipid metabolite profile and hepatic inflammation in nonalcoholic fatty liver disease

Table 3 Effects of PNPLA3 rs139051 and rs2294918 on serum profile of phospholipid metabolites in nonalcoholic fatty liver disease patients

Phospholipid metabolites	SNPs
	rs139051			rs2294918
	A/A	A/G + G/G	P value	G/G	A/A + A/G	P value
LPC 17:0	0.148 ± 0.119	0.089 ± 0.032	0.045a	0.143 ± 0.113	0.084 ± 0.023	0.023a
LPC 18:0	5.501 ± 4.064	3.482 ± 1.032	0.045a	5.199 ± 3.888	3.564 ± 0.941	0.068
LPC 20:0	0.019 ± 0.012	0.011 ± 0.005	0.013a	0.018 ± 0.011	0.010 ± 0.005	0.008a
LPC 20:1	0.035 ± 0.028	0.020 ± 0.072	0.031a	0.033 ± 0.026	0.018 ± 0.007	0.017a
LPC 20:2	0.046 ± 0.040	0.025 ± 0.090	0.037a	0.042 ± 0.038	0.027 ± 0.010	0.091
LPC O-16:0	0.128 ± 0.109	0.078 ± 0.016	0.058	0.123 ± 0.102	0.075 ± 0.016	0.038a
LPC O-16:1	0.111 ± 0.088	0.068 ± 0.016	0.046a	0.106 ± 0.083	0.067 ± 0.014	0.041a
LPC O-18:1	0.076 ± 0.071	0.041 ± 0.011	0.039a	0.072 ± 0.067	0.040 ± 0.011	0.036a
LPE 20:4	0.087 ± 0.037	0.116 ± 0.035	0.029a	0.092 ± 0.040	0.113 ± 0.034	0.143
LPE 22:6	0.091 ± 0.044	0.113 ± 0.037	0.138	0.090 ± 0.036	0.122 ± 0.046	0.035a
PC 32:1	1.574 ± 0.941	1.912 ± 1.167	0.358	1.450 ± 0.949	2.263 ± 1.036	0.030a
PE 34:0	0.312 ± 0.018	0.325 ± 0.016	0.041a	0.310 ± 0.015	0.332 ± 0.015	0.001a
PE 34:2	0.335 ± 0.187	0.309 ± 0.159	0.673	0.280 ± 0.131	0.418 ± 0.219	0.028a
PE 36:2	0.758 ± 0.349	0.702 ± 0.324	0.634	0.650 ± 0.271	0.913 ± 0.398	0.030a
PE 36:4	0.282 ± 0.142	0.324 ± 0.169	0.435	0.246 ± 0.105	0.410 ± 0.181	0.015a
PE 38:4	0.746 ± 0.349	0.830 ± 0.348	0.493	0.661 ± 0.228	1.031 ± 0.423	0.018a
PE 38:5	0.079 ± 0.036	0.079 ± 0.034	0.960	0.070 ± 0.026	0.098 ± 0.043	0.025a
PE 38:6	0.621 ± 0.431	0.613 ± 0.332	0.953	0.493 ± 0.232	0.878 ± 0.517	0.036a
PE 40:5	0.053 ± 0.026	0.064 ± 0.033	0.305	0.047 ± 0.022	0.080 ± 0.030	0.001a
PE 40:6	0.445 ± 0.316	0.451 ± 0.220	0.952	0.354 ± 0.174	0.644 ± 0.351	0.003a
PE O-36:5	0.529 ± 0.192	0.699 ± 0.276	0.041a	0.547 ± 0.171	0.707 ± 0.331	0.071

LPC: Lysophosphatidylcholine; LPCO: Lysophosphatidylcholine plasmalogen; LPE: Lysophosphatdylethanolamine; NAFLD: Nonalcoholic fatty liver disease; PC: Phosphatidylcholine; PCO: Choline plasmalogen; PE: Phosphatidylethanolamine; PEO: Ethanolamine plasmalogen; PNPLA3: Patatin-like phospholipase domain containing 3. Values are expressed as mean ± SD. ^aP < 0.05.