PNPLA3 rs139051 is associated with phospholipid metabolite profile and hepatic inflammation in nonalcoholic fatty liver disease

Table 2 PNPLA3 single nucleotide polymorphisms associated with serum lipidomics of nonalcoholic fatty liver disease patients

SNPs	Number of SNP-associated serum lipids
	CE	FFA	LPC	LPCO	LPE	PC	PCO	PE	PEO	TAG
rs139051 (A/A: A/G + G/G )	1	1	5	2	1	0	0	1	1	0
rs738408 (T/T: C/T + C/C)	1	0	0	0	0	0	0	0	0	0
rs738409 (G/G: C/G + C/C)	1	0	0	0	0	0	0	0	0	0
rs2072906 (G/G: A/G + A/A)	1	0	0	0	0	0	1	0	0	0
rs2294918 (G/G: A/A + A/G)	0	0	3	3	1	1	0	9	0	5
rs2294919 (C/C: C/T + T/T)	0	1	0	0	0	0	0	0	0	0
rs4823173 (A/A: A/G + G/G)	1	0	0	0	0	0	0	0	0	0

CE: Cholesteryl ester; FFA: Free fatty acid; LPC: Lysophosphatidylcholine; LPCO: Lysophosphatidylcholine plasmalogen; LPE: Lysophosphatdylethanolamine; NAFLD: Nonalcoholic fatty liver disease; PC: Phosphatidylcholine; PCO: Choline plasmalogen; PE: Phosphatidylethanolamine; PEO: Ethanolamine plasmalogen; PNPLA3: Patatin-like phospholipase domain containing 3; SNP: Single nucleotide polymorphisms; TAG: Triacylglycerol.