Treatment of sepsis: What is the antibiotic choice in bacteremia due to carbapenem resistant Enterobacteriaceae?

doi:10.12998/wjcc.v5.i8.324

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Aug 16, 2017; 5(8): 324-332
Published online Aug 16, 2017. doi: 10.12998/wjcc.v5.i8.324

Table 2 Resistance mechanisms of carbapenemase producing Enterobacteriaceae

Class	Genetic mutation	Clavulanic acid inhibition
Class A	Chromosomal encoded (NmcA, Sme, IMI-1, SFC-1)	Partially inhibited
Class A	Plasmid encoded (IMI-2, GES, KPC)	Partially inhibited
Class B	Metallo-β-lactamase (IMP, VIM and NDM-1, SIM, GIM, SPM)	Resistant to clavulanic acid
Class D	Plasmid encoded oxa-48	Resistant to clavulanic aci

KPC: K. pneumoniae carbapenemases; OXA: Oxacillin-hydrolising; NDM: New Delhi metallo-beta-lactamase. Table was modified from the ref.[22].

Citation: Alhashem F, Tiren-Verbeet NL, Alp E, Doganay M. Treatment of sepsis: What is the antibiotic choice in bacteremia due to carbapenem resistant Enterobacteriaceae? World J Clin Cases 2017; 5(8): 324-332
URL: https://www.wjgnet.com/2307-8960/full/v5/i8/324.htm
DOI: https://dx.doi.org/10.12998/wjcc.v5.i8.324