Case of gastric neuroendocrine carcinoma showing an interesting tumorigenic pathway

Figure 1 Histological findings of an HE-stained section of a resected specimen. A: Low-magnification image of the surgical specimen. The tumor component was composed of two lesions (a submucosal lesion and an intramucosal lesion). These two lesions were separated by muscle layer (inset: left, EVG staining; right, D2-40 immunohistochemical staining); B: NET G2 component (inset: Ki-67 positive rate, 6.5%); C: NET G3 component (inset: Ki-67 positive rate, 99.5%); D: Large cell NEC component (inset: Ki-67 positive rate, 88.1%). NEC: Neuroendocrine carcinoma; NET: Neuroendocrine tumor.